Evidence map›Paper›PMID 40175543›Full record

ArticleNature2025

A natural experiment on the effect of herpes zoster vaccination on dementia.

Markus Eyting, Min Xie, Felix Michalik, Simon Heß, Seunghun Chung, Pascal Geldsetzer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Interpreting Viral Associations in Neurodegenerative Diseases.International journal of molecular sciences · 2026
    Review
  12. Varicella zoster virus infection.Nature reviews. Disease primers · 2026
    Review
  13. Cross-tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  14. Article
  15. Review
  16. Review
  17. Herpes Zoster Vaccination and Dementia Occurrence-Correspondence.International journal of rheumatic diseases · 2026
    Article
  18. Review
  19. Article
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Markus Eyting *Division of Primary Care and Population Health, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4228-2646
Min Xie *Division of Primary Care and Population Health, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4835-7060
Felix MichalikDivision of Primary Care and Population Health, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5589-5700
Simon HeßDepartment of Economics, Vienna University of Economics and Business, Vienna, Austria.ORCID 0000-0003-1776-0930
Seunghun ChungDivision of Primary Care and Population Health, Department of Medicine, Stanford University, Stanford, CA, USA.
Pascal GeldsetzerDivision of Primary Care and Population Health, Department of Medicine, Stanford University, Stanford, CA, USA. pgeldsetzer@stanford.edu.ORCID 0000-0002-8878-5505

Funding

The impact of clinical interventions for sepsis in routine care and among detailed patient subgroups: A novel approach for causal effect estimation in electronic health record dataDP2AI171011 · NIAID · STANFORD UNIVERSITY · PI Pascal Geldsetzer · 2022 to 2026
$2.4M
The effect of antihypertensive and statin therapy on dementia incidence: a novel analytical approach in large electronic health record datasets with long follow-up times and minimal loss to follow-upR01AG084535 · NIA · STANFORD UNIVERSITY · PI Pascal Geldsetzer · 2024 to 2026
$2.2M
NIAID NIH HHS DP2 AI171011NIA NIH HHS R01 AG084535
6 · The paper itself

Abstract

Neurotropic herpesviruses may be implicated in the development of dementia

Indexed as

DementiaHerpes ZosterHerpes Zoster VaccineVaccinationAdultAgedAged, 80 and overAge FactorsElectronic Health RecordsEnglandFemaleFollow-Up StudiesHumansMaleMiddle AgedTime FactorsHerpes Zoster Vaccine

Identifiers

PMID40175543
PMCPMC12058522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.