ArticleCommunications biology2025
Rational design of chemical- and light-inducible cGAS activation based on mechanistic insights.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Recent progress in cGAS-STING agonist design and mechanisms of cancer immune modulation.RSC chemical biology · 2026Review
- Biochemical Engineering Perspective on cGAS: From Enzyme Discovery to Potential Industrial Application.Chembiochem : a European journal of chemical biology · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cyclic GMP-AMP synthase (cGAS) plays a pivotal role in the cGAS-STING pathway as a DNA sensor that binds to double-stranded DNA (dsDNA) and subsequently induces type I interferon expression, thereby contributing significantly to the innate immune response. Several human and viral proteins have been identified to enhance or inhibit cGAS activity. The underlying molecular basis that underpins these regulatory effects remain elusive. In this study, we employ the highly sensitive dcFCCS method to systematically examine phase separation and binding affinities among cGAS, dsDNA, and several accessory proteins. We reveal that the binding strength between cGAS and accessory proteins is the key factor to affect cGAS phase separation and enzymatic activity, which guide us to develop a chemical-inducible strategy and a light-inducible strategy to manipulate cGAS phase separation and immune signaling in test tubes and in living cells. Thus, our mechanistic insights offer guidance for manipulating multi-component phase separation systems.
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Registered trials
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