ArticleScientific reports2025
Association of PIV value with early mortality in ICU patients with sepsis-associated acute kidney injury from the MIMIC IV database.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Comparative Prognostic Performance of HALP, PIV, and Naples Prognostic Score in Critically Ill Patients with Sepsis: A Retrospective Multicentre Cohort Study.Journal of clinical medicine · 2026Article
- Stress hyperglycemia ratio and short-term mortality in critically ill septic patients: stratified analysis by diabetes status.BMC infectious diseases · 2026Article
- Development and internal validation of a predictive nomogram for early postoperative bacterial infections following liver transplantation in patients with hepatocellular carcinoma.Journal of gastrointestinal oncology · 2026Article
- Association of De Ritis ratio with mortality in ICU patients with sepsis-associated acute kidney injury: a retrospective multicenter cohort study.BMC infectious diseases · 2026Article
- Pan-Immune-Inflammatory Value as a Systemic Inflammation Marker Associated with Cardiovascular-Kidney-Metabolic Syndrome: Evidence from a Cross-Sectional Study of 751 Patients.Cardiorenal medicine · 2026Observational
- Multicenter cohort study reveals: composite inflammatory indexs are associated with increased risk of diabetes in patients with hypertension.Frontiers in endocrinology · 2026Article
- Prediction of all-cause in-hospital mortality after ICU admission and 1-year mortality after discharge of patients with acute kidney injury.Renal failure · 2025Article
- Association Between the C-Reactive Protein-Albumin-Lymphocyte Index and Endometriosis: Insights from the 1999-2006 National Health and Nutrition Examination Survey.International journal of women's health · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Sepsis is a severe systemic inflammatory response, and sepsis-associated acute kidney injury (SA-AKI) is one of its most common complications. The pan-immune inflammation value (PIV), a novel inflammatory index, is designed to comprehensively reflect the status of systemic immune and inflammatory responses. However, the relationship between PIV and short-term clinical outcomes in SA-AKI patients remains unclear. This study was a retrospective analysis of SA-AKI patients from the MIMIC-IV database. The Boruta algorithm was used to identify key features predicting short-term mortality in SA-AKI patients. The relationships between ln (PIV) and all-cause mortality at 28 days and 90 days were assessed via multivariate Cox proportional hazards regression, subgroup analysis, sensitivity analysis, restricted cubic spline (RCS) modelling, and Kaplan‒Meier (K-M) survival analysis. A total of 4369 patients were included in the study, of whom 57.0% were male. Boruta analysis indicated that ln (PIV) was an important clinical feature. The results of multivariable Cox regression analysis revealed a positive correlation between ln (PIV) and mortality risk at both 28 days and 90 days (HR [95% CI] = 1.057 [1.009, 1.106], P = 0.019; HR [95% CI] = 1.075 [1.032, 1.120], P < 0.001). The RCS model revealed a nonlinear relationship between ln (PIV) and mortality at 28 and 90 days, with a critical threshold of 6.72. Above this threshold, a higher ln (PIV) was associated with increased mortality risk at both time points; sensitivity analyses confirmed that this association remained significant after specific patients were excluded. Subgroup analyses revealed that ln (PIV) significantly affected short-term mortality in diabetic patients (P < 0.05). Ln (PIV) is closely associated with short-term mortality in ICU patients with SA-AKI, suggesting its potential application in early risk assessment and clinical intervention.
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