Evidence map›Paper›PMID 40175444›Full record

ArticleScientific reports2025

Distinct prognostic implications of blood neuronal and astroglial biomarkers in neuromyelitis optica spectrum disorders versus multiple sclerosis.

Wangyong Shin, Eun-Jae Lee, Dayoung Seo, Bum Joon Choi, Inhye Jang, Jin Hee Kim, Lynkyung Choi, Keonwoo Kim, Ji-Yon Kim, Hee-Jae Jung and 3 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Wangyong ShinDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Eun-Jae LeeDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea. eunjae.lee@amc.seoul.kr.
Dayoung SeoDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Bum Joon ChoiDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Inhye JangDepartment of Medicine, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul, South Korea.
Jin Hee KimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Lynkyung ChoiDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Keonwoo KimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Ji-Yon KimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Hee-Jae JungDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Hyemi LeeDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Hyunjin KimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Young-Min LimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea. limy@amc.seoul.kr.

Funding

Asan Medical Center 2023IP0077-1Korea Health Technology R&D Project through the Korea Health Industry Development Institute HR21C0198National Research Foundation of Korea No. 2023R1A2C2007798
6 · The paper itself

Abstract

Research on neuronal and astroglial markers for predicting outcomes in aquaporin-4 antibody-seropositive neuromyelitis optica spectrum disorders (NMOSD) remains limited. We aimed to evaluate the prognostic value of blood biomarkers for neuronal and astroglial damage in NMOSD compared with multiple sclerosis (MS). Patients with NMOSD and MS were prospectively recruited, and baseline serum levels of neurofilament light (sNfL) and glial fibrillary acidic protein (sGFAP) were measured. The correlations between these biomarkers and neurological disability (Expanded Disability Status Scale, EDSS) and cognitive function (iPad-based processing speed test, PST) were analyzed at baseline and two years later. In this cohort of 41 NMOSD and 92 MS patients, blood biomarkers demonstrated distinct patterns of association with current and future outcomes. In NMOSD, sGFAP was consistently linked to neurological disability and cognitive impairment over time, reflecting astrocytopathy with minimal silent neurodegeneration. In MS, sGFAP did not correlate with baseline EDSS but showed associations with future scores. Notably, sNfL was more strongly associated with future PST scores than baseline scores (p = 0.005), suggesting ongoing neurodegeneration. These results underscore that blood biomarkers are predictive of both current and future outcomes in NMOSD and MS, with differing patterns reflecting the unique pathogenesis of each disease.

Indexed as

AstrocytesBiomarkersGlial Fibrillary Acidic ProteinMultiple SclerosisNeurofilament ProteinsNeuromyelitis OpticaNeuronsAdultFemaleHumansMaleMiddle AgedPrognosisProspective StudiesBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsBiomarkersGlial fibrillary acidic proteinMultiple sclerosisNeurofilament lightNeuromyelitis Optica spectrum disorder

Identifiers

PMID40175444
PMCPMC11965290

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