Evidence map›Paper›PMID 40175437›Full record

ArticleScientific reports2025

Loneliness and biomarkers of brain pathology in people with subjective cognitive decline.

Mariola Zapater-Fajarí, Isabel Crespo-Sanmiguel, Nira Cedres, Therese Rydberg Sterner, Lina Rydén, Simona Sacuiu, Margda Waern, Anna Zettergren, Henrik Zetterberg, Kaj Blennow and 6 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mariola Zapater-Fajarí *Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Isabel Crespo-Sanmiguel *Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Nira CedresFacultad de Ciencias de La Salud, Universidad Fernando Pessoa Canarias, Las Palmas, España.
Therese Rydberg SternerCentre for Ageing and Health, The University of Gothenburg, Gothenburg, Sweden.
Lina RydénCentre for Ageing and Health, The University of Gothenburg, Gothenburg, Sweden.
Simona SacuiuDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Margda WaernCentre for Ageing and Health, The University of Gothenburg, Gothenburg, Sweden.
Anna ZettergrenCentre for Ageing and Health, The University of Gothenburg, Gothenburg, Sweden.
Henrik ZetterbergNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Kaj BlennowNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Silke KernCentre for Ageing and Health, The University of Gothenburg, Gothenburg, Sweden.
Vanesa HidalgoIIS Aragón, Department of Psychology and Sociology, Area of Psychobiology, University of Zaragoza, Teruel, Spain.
Alicia SalvadorLaboratory of Cognitive Social Neuroscience, Department of Psychobiology and IDOCAL, University of Valencia, Valencia, Spain.
Eric WestmanDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Ingmar SkoogNeuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Daniel FerreiraDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden. daniel.ferreira.padilla@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loneliness is a neuropsychiatric symptom that has been associated with cognitive impairment and dementia. We aimed to investigate whether depressive symptomatology and biomarkers of Alzheimer's disease (AD) and cerebrovascular disease (CVD) are associated with loneliness. Secondly, we aimed to investigate whether loneliness, depressive symptomatology, and biomarkers of AD and CVD are associated with subjective cognitive decline (SCD). We included 215 cognitively unimpaired participants (70 y/o) with cerebrospinal fluid biomarkers, magnetic resonance imaging, and questionnaires for loneliness, depressive symptomatology, and SCD. For aim 1, our findings showed that CVD and depressive symptomatology were the most relevant measures to discriminate people with loneliness. For aim 2, a random forest classification model showed that loneliness contributed to discriminate individuals with SCD, but logistic regression showed that its partial predictive effect was non-significant when depressive symptomatology and AD biomarkers were included in the models. We conclude that loneliness is associated with SCD, CVD, and depressive symptomatology. Given the complex interplay between loneliness, depressive symptomatology, and SCD, more research is needed to fully clarify the unique role of each neuropsychiatric symptom in relation to biomarkers of brain pathology.

Indexed as

Alzheimer DiseaseBiomarkersBrainCerebrovascular DisordersCognitive DysfunctionLonelinessAgedAged, 80 and overDepressionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedBiomarkersAlzheimer’s disease biomarkersCerebrovascular diseaseDepressive symptomatologyLonelySubjective cognitive impairment

Identifiers

PMID40175437
PMCPMC11965453

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.