Evidence map›Paper›PMID 40175415›Full record

ArticleScientific reports2025

Content-based image retrieval assists radiologists in diagnosing eye and orbital mass lesions in MRI.

Josef Lorenz Rumberger, Winna Lim, Benjamin Wildfeuer, Elisa Birgit Sodemann, Augustin Lecler, Simon Stemplinger, Ahi Sema Issever, Ali Sepahdari, Sönke Langner, Dagmar Kainmueller and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Josef Lorenz Rumberger *Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Winna Lim *Department of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Berlin, Germany.
Benjamin WildfeuerDepartment of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Berlin, Germany.
Elisa Birgit SodemannDepartment of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Berlin, Germany.
Augustin LeclerHôpital Fondation Adolphe de Rothschild, Paris, France.
Simon StemplingerIndependent Researcher, Berlin, Germany.
Ahi Sema IsseverDepartment of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Berlin, Germany.
Ali SepahdariDiagnostic Neuroradiology, Department of Radiology, Scripps Clinic Medical Group, La Jolla, CA, USA.
Sönke LangnerGreifswald University Medicine, Greifswald, Germany.
Dagmar KainmuellerMax-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Bernd HammDepartment of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Berlin, Germany.
Katharina Erb-EignerDepartment of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Berlin, Germany. katharina.erb@charite.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosing eye and orbit pathologies through radiological imaging presents considerable challenges due to their low prevalence, the extensive range of possible conditions, and their variable presentations, necessitating substantial domain-specific expertise. This study evaluates whether a ML-based content-based image retrieval (CBIR) tool, combined with a curated database of orbital MRI cases with verified diagnoses, can enhance diagnostic accuracy and reduce reading time for radiologists diagnosing eye and orbital pathologies. It explores whether this tool alone, or in combination with status quo reference tools (e.g. Radiopaedia.org, StatDx) provides these benefits. In a multi-reader, multi-case study involving 36 radiologists and 48 retrospective orbital MRI cases, participants diagnosed eight cases: four using status quo reference tools and four with the addition of the CBIR tool. Analysis using linear mixed-effects models revealed significant improvements in diagnostic accuracy when using the CBIR tool alone (55.88% vs. 70.59%, p = 0.03, odds ratio = 2.07) and an even greater improvement when used alongside status quo tools (55.88% vs. 83.33%, p = 0.02, odds ratio = 3.65). Reading time decreased when using the CBIR tool alone (334 s vs. 236 s, p < 0.001) but increased when used in conjunction with status quo tools (334 s vs. 396 s, p < 0.001). These findings indicate that CBIR tools can significantly enhance diagnostic accuracy for eye and orbit diagnostics, though their impact on reading time varies.

Indexed as

Magnetic Resonance ImagingOrbital NeoplasmsRadiologistsAdultAgedFemaleHumansMaleMiddle AgedOrbitRetrospective Studies

Identifiers

PMID40175415
PMCPMC11965554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.