Evidence map›Paper›PMID 40175370›Full record

ArticleNature communications2025

A LTR retrotransposon insertion leads to leafy phenotype in maize by elevating ZmOM66 expression.

Xuemei Du, Zhuoyi Xu, Jiawen Lu, Yan Chen, Xinpeng Gao, Jie Zhang, Cheng He, Liying Huang, Wei Guo, Yangbo Cui and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xuemei Du *State Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-1781-7207
Zhuoyi Xu *State Key Laboratory of Maize Bio-Breeding, Frontiers Science Center for Molecular Design Breeding, Beijing Innovation Center for Crop Seed Technology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Jiawen LuState Key Laboratory of Maize Bio-Breeding, Frontiers Science Center for Molecular Design Breeding, Beijing Innovation Center for Crop Seed Technology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Yan ChenState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Xinpeng GaoState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Jie ZhangState Key Laboratory of Maize Bio-Breeding, Frontiers Science Center for Molecular Design Breeding, Beijing Innovation Center for Crop Seed Technology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Cheng HeState Key Laboratory of Maize Bio-Breeding, Frontiers Science Center for Molecular Design Breeding, Beijing Innovation Center for Crop Seed Technology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-6148-7487
Liying HuangState Key Laboratory of Maize Bio-Breeding, Frontiers Science Center for Molecular Design Breeding, Beijing Innovation Center for Crop Seed Technology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Wei GuoState Key Laboratory of Maize Bio-Breeding, Frontiers Science Center for Molecular Design Breeding, Beijing Innovation Center for Crop Seed Technology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Yangbo CuiState Key Laboratory of Maize Bio-Breeding, Frontiers Science Center for Molecular Design Breeding, Beijing Innovation Center for Crop Seed Technology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Xiaoli WangState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Junmin AiState Key Laboratory of Maize Bio-Breeding, Frontiers Science Center for Molecular Design Breeding, Beijing Innovation Center for Crop Seed Technology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Li LiState Key Laboratory of Maize Bio-Breeding, Frontiers Science Center for Molecular Design Breeding, Beijing Innovation Center for Crop Seed Technology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Yu CuiState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Yunjun LiuState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Junjie FuState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-4702-2392
Riliang GuState Key Laboratory of Maize Bio-Breeding, Frontiers Science Center for Molecular Design Breeding, Beijing Innovation Center for Crop Seed Technology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China. rilianggu@cau.edu.cn.
Jianhua WangState Key Laboratory of Maize Bio-Breeding, Frontiers Science Center for Molecular Design Breeding, Beijing Innovation Center for Crop Seed Technology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China. wangjh63@cau.edu.cn.
Guoying WangState Key Laboratory of Crop Gene Resources and Breeding, National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China. wangguoying@caas.cn.

Funding

Chinese Universities Scientific Fund 2023TC188National Natural Science Foundation of China (National Science Foundation of China) 32201843
6 · The paper itself

Abstract

Leafy (Lfy1) is a classical dominant mutant showing more leaf number above primary ear and later flowering time in maize, but the causal gene together with its underlying genetic mechanism are unknown. Here, we report the cloning of Lfy1 mutant, and find that a retrotransposon insertion leads to leafy phenotype by elevating expression of its neighboring gene ZmOM66. ZmOM66 encodes an AAA+ ATPase that locate in mitochondria and interacts with itself. ZmOM66 overexpression affects the starch degradation, as well as contents of glucose, pyruvic acid, trehalose-6-phosphate, and TCA cycle related amino acids, and influences expression patterns of circadian clock genes. Moreover, expressions of floral related genes, including photoperiod regulated gene ZmPHYB1, integrator genes ZCN7, ZNC8 and ZCN12, and floral meristem identity genes ZMM4, ZMM15, and MASD67, are also significantly decreased by ZmOM66 overexpression. These results deepen our understanding of the regulatory mechanism of floral transition and leaf number in plant.

Indexed as

Gene Expression Regulation, PlantPlant LeavesPlant ProteinsRetroelementsTerminal Repeat SequencesZea maysFlowersMutagenesis, InsertionalPhenotypePhotoperiodPlant ProteinsRetroelements

Identifiers

PMID40175370
PMCPMC11965440

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.