Evidence map›Paper›PMID 40175164›Full record

ArticleClinical and translational allergy2025

Radiological score, asthma and NSAID-exacerbated respiratory disease predict relapsing chronic rhinosinusitis.

Markus Lilja, Anni Koskinen, Sari Hammarèn-Malmi, Anu Laulajainen-Hongisto, Jura Numminen, Jyri Myller, Seija Vento, Elina Penttila, Maija Hytönen, Paula Virkkula and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Markus LiljaDepartment of Allergology, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Anni KoskinenDepartment of Allergology, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Sari Hammarèn-MalmiDepartment of Allergology, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Anu Laulajainen-HongistoDepartment of Allergology, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Jura NumminenDepartment of Otorhinolaryngology & Head and Neck Surgery, Faculty of Medicine and Health Technology, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere University, Tampere, Finland.
Jyri MyllerDepartment of Otorhinolaryngology, Wellbeing Services County of Päijät-Häme, Päijät-Häme Central Hospital, Lahti, Finland.
Seija VentoDepartment of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Elina PenttilaDepartment of Otorhinolaryngology, Kuopio University Hospital, Wellbeing Services County of North Savo, Kuopio, Finland.
Maija HytönenDepartment of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Paula VirkkulaDepartment of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Peter W HellingsDepartment of Otorhinolaryngology, Head and Neck Surgery, UZ Leuven Campus Gasthuisberg, Upper Airways Research, University of Ghent, Leuven, Belgium.
Sven F SeysAllergy and Clinical Immunology Research Group, Department of Microbiology, Immunology & Transplantation, KU Leuven, Leuven, Belgium.
John LeeDepartment of Otolaryngology-Head and Neck Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Heini HuhtalaFaculty of Social Sciences, Tampere University, Tampere, Finland.
Johanna SahlmanDepartment of Otorhinolaryngology, Kuopio University Hospital, Wellbeing Services County of North Savo, Kuopio, Finland.ORCID https://orcid.org/0000-0002-6531-5797
Sanna Toppila-SalmiDepartment of Allergology, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0003-0890-6686

Funding

Allergy Research FoundationFinnish Association of Otorhinolaryngology and Head and Neck SurgeryFoundation of the Finnish Anti-Tuberculosis AssociationJane ja Aatos Erkon SäätiöState funding for university-level health research TYH2019322State funding for university-level health research TYH TYH2024309The Competitive Research Funding of the Tampere Medical Research Fund of Tampere University HospitalThe Finnish Medical FoundationThe Tampere Tuberculosis FoundationVäinö ja Laina Kiven SäätiöYrjö Jahnssonin Säätiö
6 · The paper itself

Abstract

objectivesThe aim was to evaluate the predictive potential of Sinonasal Radiological (SR) and the Lund-Mackay (LM) score of sinus computed tomography (CT) scans on postoperative relapses of chronic rhinosinusitis (CRS). MATERIALS AND

methodsCRS patients (n = 483, 12-80 years) underwent routine sinus CT scans. The SR score was defined by obstructed frontal recess (0 = no, 1 = yes) and visualization of middle and inferior turbinate (0 = anatomy can be easily visualized, 1 = anatomy cannot be easily visualized) on each side (a total of 0-6 points). Associations were analyzed by nonparametric, survival and Cox's proportional hazard models.

resultsRevision endoscopic sinus surgery (ESS) was performed in 133 (28.0%) patients on average (min-max) of 3.2 (0-12) years after performing the sinus CT scans. Of the 408 patients who underwent the baseline ESS, high preoperative SR or LM scores significantly predicted revision ESS (p < 0.001) and peroral corticosteroid courses purchased during the follow-up (p = 0.009 and p < 0.001, respectively for SR- and LM-scores). In multivariable analysis, both SR score and asthma and/or NSAID exacerbated respiratory disease (N-ERD) were significantly associated with revision ESS risk (p = 0.035, p = 0.007, respectively).

conclusionLM and SR and a history of asthma or N-ERD predict CRS relapses, which may help in decision-making.

Indexed as

antrochoanal polypaspirin exacerbated respiratory diseaseaspirin intoleranceESSinflammationnasal polyprecurrencerevision surgerysinusitissinus surgery

Identifiers

PMID40175164
PMCPMC11964611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.