Evidence map›Paper›PMID 40175126›Full record

ArticleNMR in biomedicine2025

In Vivo Brain B

Paul S Jacobs, Anshuman Swain, Neil E Wilson, Wyger M Brink, Abeer Mathur, Ravi Prakash Reddy Nanga, Mark A Elliott, John A Detre, Ravinder Reddy

Abstract read
In one paragraph

Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Metamaterial Antennas Enhance MRI of the Eye and Occipital Brain.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paul S JacobsCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3566-4010
Anshuman SwainCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Neil E WilsonCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0002-7766-2929
Wyger M BrinkMagnetic Detection and Imaging Group, TechMed Centre, University of Twente, Enschede, The Netherlands.
Abeer MathurCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ravi Prakash Reddy NangaCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mark A ElliottCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
John A DetreCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ravinder ReddyCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
NIA NIH HHSNIBIB NIH HHS P41 EB029460
6 · The paper itself

Abstract

Nuclear Overhauser effect (NOE) MRI has been used for in vivo brain imaging to assess lipid and protein composition and benefits from 7 T field strengths due to the larger chemical shift dispersion. However, a continuing challenge is signal drop off observed in regions such as the medial temporal lobes due to "standing wave" effects from shorter radiofrequency (RF) wavelengths at ultra-high fields. 2D periodic unit cell metasurfaces have been a promising approach for providing improvements in anatomical imaging but have not yet been evaluated in chemical exchange saturation transfer (CEST)-based sequences. Here, we report the use of metasurfaces for enhancement of NOE imaging as well as for improvement of Lorentzian line fitting of full Z-spectrum data. 3D NOE image data, B

Indexed as

BrainImage EnhancementMagnetic Resonance ImagingAdultFemaleHumansMaleB1+ homogeneitymetasurfacesNOEultra‐high field

Identifiers

PMID40175126
PMCPMC11964795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.