ArticleJournal of the American College of Cardiology2025
New Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals.
Article in Journal of the American College of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Digital phenotyping of aortic stenosis-related remodeling reveals complementary structural, electrical, and hemodynamic signatures.medRxiv : the preprint server for health sciences · 2026Article
- Mitochondrial cardiovascular diseases: molecular mechanisms, multi-omics exploration and therapeutic strategies.Journal of advanced research · 2026Review
- Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk.Nature genetics · 2026Article
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18 authors.
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Abstract
backgroundMild aortic stenosis (AS) is associated with adverse outcomes but is incompletely defined.
objectivesThe purpose of this study was to examine the epidemiology of AV function measured without clinical indications.
methodsWe developed a deep learning model to measure aortic valve (AV) area, peak velocity, and mean gradient in velocity-encoded cardiac magnetic resonance imaging in 62,902 UK Biobank participants. Study findings were externally validated in NEDA (National Echo Database Australia), a clinical cohort of 365,870 people.
resultsFrom measuring reference ranges of AV function in a healthy subcohort (n = 41,859), we observed a natural boundary between normal and abnormal AV hemodynamics (>95th percentile) that we refer to as "mild AS
conclusionsWe report a large-scale study of AV hemodynamics and identify a population threshold between normal and abnormal AV function. Mild AS, as defined by the proposed criteria, was linked to adverse outcomes in the UK Biobank and in NEDA.
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