ArticleAJNR. American journal of neuroradiology2025
Synthetic MRI in Progressive MS: Associations with Disability.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
background and purposeSynthetic MRI (SyMRI) is a short-time acquisition sequence that generates different contrast-weighted images based on the measurement of tissue properties and provides quantitative volumetric, relaxation, and myelin maps. It has been used as an alternative to conventional MRI sequences in relapsing-remitting MS for detecting focal lesions and volumetric analysis. This study aimed to find an SyMRI variable associated with an Expanded Disability Status Scale (EDSS) ≥ 6 in progressive patients. MATERIALS AND
methodsTwenty-four patients with progressive MS underwent SyMRI with a 2D axial QRAPMASTER pulse sequence. We analyzed volumetric parameters, global myelin fraction (MyCF), and quantitative values derived from maps of proton density, R1, R2, and myelin for the masks: normal-appearing white and gray matter, lesion, and corpus callosum. A
resultsPatients were categorized into 2 groups (EDSS < 6 versus ≥ 6). Variables with significant differences between groups were: brain parenchymal fraction (
conclusionsOur results confirm differences in volumetric parameters by EDSS by using a single MRI acquisition. Additionally, higher MyCF values were associated with lower disability, highlighting SyMRI and myelin quantification as potential tools for clinical practice.
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