SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2025
Risk of malignant transformation and infections in congenital lung malformations in adults: a systematic review.
Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Surgical Management of Congenital Lung Malformations: Indications, Timing, and Outcomes.Journal of chest surgery · 2026Review
- Congenital pulmonary airway malformation mimicking lung cancer in adults: a pitfall in oncologic diagnosis.Quantitative imaging in medicine and surgery · 2026Article
- A lifespan pooled analysis of 832 cases: characterizing the lifespan profile of clinical presentations and comorbidities in congenital pulmonary airway malformation.Orphanet journal of rare diseases · 2026Article
- Endovascular Embolization of Pulmonary Sequestration in Children with Contraindications to Surgery: A Two-Centre Experience with Long-Term Follow-Up.Children (Basel, Switzerland) · 2026Article
- Thirty-year nationwide research on epidemiology, treatment, and outcomes of congenital lung malformations.Scientific reports · 2026Article
- Long-term outcomes after operative versus conservative management of congenital thoracic malformations: a propensity-matched cohort study.Pediatric surgery international · 2026Article
- Pulmonary Malignancies in Adults With Congenital Lung Malformations: A Scoping Review.JTO clinical and research reports · 2026Review
- Rising detection of congenital pulmonary airway malformations and a pragmatic institutional algorithm: a four-patient thoracoscopic case series.Journal of surgical case reports · 2026Article
- Congenital Pulmonary Airway Malformation Type 1 With KRAS Mutation: A Case Report and Literature Review.Case reports in obstetrics and gynecology · 2026Article
- Bronchogenic Cyst at the Terminal Ileum Presenting as an Enteric Duplication: A Case Report.European journal of pediatric surgery reports · 2026Article
- Congenital pulmonary airway malformation type 2 associated with intralobar pulmonary sequestration in an adult patient: a case report.Future science OA · 2025Article
- A Case of Hybrid of Congenital Pulmonary Airway Malformation and Anomalous Systemic Blood Supply Presenting Elevated Serum Levels of Carbohydrate Antigen 19-9.Respirology case reports · 2025Article
- Reply to: Comment on: Risk of malignant transformation and infections in congenital lung malformations in adults: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025Article
- Comment on: Risk of malignant transformation and infections in congenital lung malformations in adults: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025Article
- Critical Care Dilemma: Complex Congenital Pulmonary Airway Malformation With Pulmonary Hypertension in a Neonate.Cureus · 2025Article
- Postnatal outcomes of sonographically suspected isolated congenital lung anomalies.Pediatric surgery international · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough there is agreement on surgically removing symptomatic congenital lung malformations (CLMs), the management of asymptomatic cases remains controversial. Some paediatric surgeons suggest conservative management for asymptomatic cases due to the low perceived risk of developing symptoms or malignancy. This study aimed to investigate the characteristics and management of adults with CLMs.
methodsFollowing PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a systematic review was conducted to find studies reporting on adult patients (aged ≥15 years) with CLMs.
resultsOut of 12 908 studies reviewed from 1947 to 2024, 653 studies met the inclusion criteria, covering 980 patients. None of the patients had a prenatal diagnosis. The mean±sd age at surgery was 39.4±15.7 years (range 15-86). A total of 74.4% of adults with CLMs presented with symptoms, leading to the detection of CLM. Pneumonia was the most common symptom in congenital pulmonary airway malformation (CPAM) and intralobar sequestration, with over 30% of these patients experiencing recurrent respiratory infections. In 11.7% of adults, CLMs harboured tumours at the time of surgical removal, with CPAM associated with lung tumours in over 20% of cases.
conclusionsThoracic surgeons recommend surgical resection for all adult CLM patients, including asymptomatic cases, due to risks of infections and malignancy. Conservative management was considered only when surgery was not feasible.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.