Evidence map›Paper›PMID 40174899›Full record

ReviewContact dermatitis2025

Contact Urticaria and Related Conditions: Clinical Review.

Mojca Bizjak, Olivier Aerts, David Pesqué, Melba Muñoz, Riccardo Asero, Margarida Gonçalo, Thomas Rustemeyer, Mitja Košnik, Mark Kačar, An Goossens and 6 more

Abstract readReview
In one paragraph

Review in Contact dermatitis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Update on occupational contact urticaria: a systematic narrative review.Current opinion in allergy and clinical immunology · 2026
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Observational
  6. Cold Urticaria: From Wheals to Anaphylaxis.Allergy, asthma & immunology research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mojca BizjakDivision of Allergy, University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.ORCID https://orcid.org/0000-0003-2595-468X
Olivier AertsDepartment of Dermatology, Antwerp, Belgium.ORCID https://orcid.org/0000-0002-0076-2887
David PesquéDermatology Department, Hospital del Mar Research Institute, Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.ORCID https://orcid.org/0000-0002-5821-9780
Melba MuñozInstitute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0003-3386-4502
Riccardo AseroClinica San Carlo, Ambulatorio di Allergologia, Milano, Italy.ORCID https://orcid.org/0000-0002-8277-1700
Margarida GonçaloClinic of Dermatology, University Hospital, Coimbra Local Health Unit and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0001-6842-1360
Thomas RustemeyerDermato-Allergology and Occupational Dermatology Amsterdam University Medical Centers, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-7580-0684
Mitja KošnikDivision of Allergy, University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.ORCID https://orcid.org/0000-0002-4701-7374
Mark KačarDivision of Allergy, University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.ORCID https://orcid.org/0000-0003-2035-6998
An GoossensFaculty of Medicine, Catholic University of Leuven (KU Leuven), Leuven, Belgium.ORCID https://orcid.org/0000-0002-9805-3439
Jose Hernán AlfonsoDepartment of Dermatology & Venereology, Oslo University Hospital - Rikshospitalet, Oslo, Norway.ORCID https://orcid.org/0000-0003-3504-2473
Charlotte G MortzDepartment of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0001-8710-0829
Maryam Ali Al-NesfAllergy and Immunology Division, Department of Medicine, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0001-9354-0214
Joachim W FluhrInstitute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0003-3610-0698
Howard I MaibachDepartment of Dermatology, University of California San Francisco, San Francisco, California, USA.
Ana Maria Giménez-ArnauDermatology Department, Hospital del Mar Research Institute, Universitat Pompeu Fabra (UPF), Barcelona, Spain.ORCID https://orcid.org/0000-0001-5434-7753

Funding

Javna Agencija za Raziskovalno Dejavnost RS P3-0360
6 · The paper itself

Abstract

Contact urticaria (CoU) is an immediate contact reaction occurring within minutes to an hour after exposure to specific proteins or chemicals. CoU is categorised into non-immunologic (NI-CoU) and immunologic (I-CoU) types, with I-CoU potentially leading to anaphylaxis. Both forms of CoU can be associated with protein contact dermatitis and the CoU syndrome. Patients with I-CoU may also have other type I (immediate) allergic diseases, such as allergic conjunctivitis, rhinitis, asthma or food allergy. This review provides a detailed overview of CoU and related conditions, focusing on triggers, diagnostic methods and management strategies. NI-CoU is typically triggered by low molecular weight chemicals, while I-CoU involves IgE-mediated hypersensitivity to both high molecular weight proteins and low molecular weight chemicals. Early diagnosis is crucial, though CoU is often underrecognized. The diagnostic approach includes a thorough medical history, physical examination, evaluation of photographs, (non)invasive skin tests and in vitro assessments. Management strategies prioritise trigger avoidance and pharmacological treatments when avoidance is not fully possible. For I-CoU, second-generation H

Indexed as

Dermatitis, Allergic ContactUrticariaAnti-Allergic AgentsHumansAnti-Allergic Agentsanaphylaxiscontact urticariainducible urticariaoccupational urticariaprotein contact dermatitis

Identifiers

PMID40174899
PMCPMC12223959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.