Evidence map›Paper›PMID 40174666›Full record

ArticleJournal of molecular biology2025

Distinct Allosteric Networks in CDK4 and CDK6 in the Cell Cycle and in Drug Resistance.

Wengang Zhang, Devin Bradburn, Gretchen Heidebrink, Yonglan Liu, Hyunbum Jang, Ruth Nussinov, Mardo Kõivomägi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Uncovering cancer dependencies in peptide-interacting protein pockets.bioRxiv : the preprint server for biology · 2026
    Article
  7. Allostery in Biomolecular Condensates.Journal of molecular biology · 2026
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Wengang ZhangCancer Innovation Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Devin BradburnLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
Gretchen HeidebrinkLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
Yonglan LiuCancer Innovation Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Hyunbum JangCancer Innovation Laboratory, National Cancer Institute, Frederick, MD 21702, USA; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Ruth NussinovCancer Innovation Laboratory, National Cancer Institute, Frederick, MD 21702, USA; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: NussinoR@mail.nih.gov.
Mardo KõivomägiLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address: mardo.koivomagi@nih.gov.

Funding

Biochemical mechanisms cyclin-dependent kinases use to control cell divisionZIABC012133 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KOIVOMAGI, MARDO · 2023 to 2025
$4.3M
Protein Structure, Stability, and Amyloid FormationZ01BC010440 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSINOV, RUTH · 2002 to 2008
$1.4M
Biomolecular Recognition and Binding MechanismsZ01BC010441 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSINOV, RUTH · 2002 to 2008
$1.2M
Intramural NIH HHS Z01 BC010440Intramural NIH HHS Z01 BC010441Intramural NIH HHS ZIA BC012133
6 · The paper itself

Abstract

Cyclin-dependent kinases 4 and 6 (CDK4 and CDK6) are key regulators of the G

Indexed as

Cell CycleCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Drug Resistance, NeoplasmAllosteric RegulationHumansMolecular Dynamics SimulationPhosphorylationProtein BindingProtein ConformationProtein Kinase InhibitorsCDK4 protein, humanCDK6 protein, humanCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Protein Kinase Inhibitorsallosteric drug discoverycancercyclin-dependent kinases (CDKs)G(1) cell cycle phaseG(1)/S transition

Identifiers

PMID40174666
PMCPMC12266608

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.