ArticleJournal of advanced research2026
Multifunctional nanoplatform for tumor chemodynamic and self-amplified photodynamic cascade therapy.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- PEG-GE11-modified nanoplatform for co-delivery of cisplatin and plumbagin in targeted therapy of oral squamous cell carcinoma.RSC advances · 2026Article
- Dual-Metal Organic Framework Nanozyme for Synergistic Photothermal-Chemodynamic Therapy: Copper-Molybdenum Synergism in Gastric Cancer Treatment.International journal of nanomedicine · 2026Article
- Nanosystem-Mediated Phototherapy (PDT/PTT) - Chemodynamic Therapy for Synergistic Antitumor Therapy: Strategies and Advances.International journal of nanomedicine · 2026Review
- Dual Sensitization Enables Synergistic Photodynamic Therapy and Radiotherapy for Breast Cancer.Research (Washington, D.C.) · 2026Article
- From Barrier to Gateway: Nanomaterials Reshaping the Tumor Microenvironment for Therapy.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction5-Aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) has demonstrated considerable potential in breast cancer treatment. However, its efficacy is limited by low tissue selectivity and the rapid conversion of 5-ALA to non-photosensitive heme in tumor tissues, reducing its therapeutic effectiveness.
objectivesThis study aims to develop a multifunctional nanomedicine to enhance 5-ALA's PDT efficacy while introducing chemodynamic therapy (CDT) for synergistic tumor inhibition. By designing a zinc-ion-doped cuprous metal-organic framework (MOF) nanocarrier loaded with 5-ALA (5-ALA@Zn-CuTz), we seek to improve tumor targeting, prolong photosensitizer retention, and enhance therapeutic outcomes.
methodsTo enhance biocompatibility and active tumor targeting, the surface of 5-ALA@Zn-CuTz nanoparticles (NPs) was modified with a platelet membrane (PM), forming 5-ALA@Zn-CuTz@PM NPs. The therapeutic efficacy was evaluated in vitro and in vivo using mice breast cancer models. Cellular uptake, reactive oxygen species (ROS) generation, and tumor inhibition efficiency were analyzed through fluorescence imaging, biochemical assays, and histological analysis.
resultsUpon intravenous administration, 5-ALA@Zn-CuTz@PM NPs selectively accumulated in breast cancer cells. Within the tumor, Zn
conclusion5-ALA@Zn-CuTz@PM NPs effectively enhance PDT efficacy through selective tumor targeting and HO-1 inhibition while simultaneously leveraging CDT for additional tumor suppression. The combined PDT/CDT strategy demonstrated superior therapeutic outcomes, highlighting the potential of this nanoplatform as a promising approach for breast cancer treatment.
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