Evidence map›Paper›PMID 40173349›Full record

ArticleRetinal cases & brief reports2026

POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY FEATURES OF THE REPAIR TISSUE AFTER RETINAL PIGMENT EPITHELIUM TEAR AND FUNCTIONAL CORRELATION WITH VISUAL OUTCOMES.

Keiko Azuma, Daisuke Santo, Satoshi Sugiyama, Nobuyori Aoki, Shuichiro Aoki, Kohdai Kitamoto, Ryo Terao, Tatsuya Inoue, Ryo Obata

Abstract readCase Reports
In one paragraph

Article in Retinal cases & brief reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keiko AzumaDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Daisuke SantoEngineering Department, Tomey Corporation, Nagoya, Aichi, Japan.
Satoshi SugiyamaEngineering Department, Tomey Corporation, Nagoya, Aichi, Japan.
Nobuyori AokiEngineering Department, Tomey Corporation, Nagoya, Aichi, Japan.
Shuichiro AokiDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Kohdai KitamotoDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Ryo TeraoDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Tatsuya InoueDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Ryo ObataDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate changes in melanin distribution and retinal sensitivity after a retinal pigment epithelium tear in neovascular age-related macular degeneration.

methodsFive cases of neovascular age-related macular degeneration with retinal pigment epithelium tears involving the fovea within 1 month of onset were examined. Using polarization-sensitive optical coherence tomography, entropy-a quantitative indicator of melanin distribution-was measured at baseline and 6 months at the level of Bruch membrane. Retinal sensitivity was assessed with a microperimeter, and entropy was averaged across 25 grids within a 6° radius. The relationship between changes in entropy and retinal sensitivity was analyzed.

resultsEntropy significantly increased in the tear area (from 0.18 to 0.22, P< 0.0001), whereas it decreased in the nontear area. Retinal sensitivity also significantly increased in the tear area (from 12.7 to 16.3 dB, P <0.0001). Although entropy and retinal sensitivity were not directly correlated in each area, their changes were significantly correlated, regardless of area type. Changes in central grid entropy were associated with changes in logarithm of the minimum angle of resolution visual acuity.

conclusionSix months postretinal pigment epithelium tear, entropy and retinal sensitivity increased in tear areas; entropy changes were linked to retinal sensitivity and visual acuity, indicating functional adjustments after the tear.

Indexed as

Retinal PerforationsRetinal Pigment EpitheliumTomography, Optical CoherenceVisual AcuityWet Macular DegenerationAgedAged, 80 and overFemaleHumansMalefunctional adjustmentmelanin distributionmicroperimetryneovascular age-related macular degenerationpolarization entropypolarization-sensitive optical coherence tomographyretinal pigment epithelium tearretinal sensitivity

Identifiers

PMID40173349
PMCPMC13166061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.