Evidence map›Paper›PMID 40173321›Full record

ArticleMagnetic resonance in medicine2025

Open-source implementation of X-nuclear sequences using the Pulseq framework.

Xiaoxi Liu, Di Cui, Peder E Z Larson, Dirk Mayer, Andreas Korzowski, Jon-Fredrik Nielsen, Rolf F Schulte, Changhua Mu, Lucas Carvajal, Duan Xu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. A vendor-neutral functional MRI acquisition protocol for multi-site studies.medRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaoxi LiuDepartment of Radiology and Biomedical Imaging, University of California, California, USA.ORCID 0000-0003-0657-8922
Di CuiDepartment of Radiology and Biomedical Imaging, University of California, California, USA.ORCID 0000-0001-7069-339X
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, California, USA.ORCID 0000-0003-4183-3634
Dirk MayerDepartment of Diagnostic Radiology and Nuclear Medicine, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Andreas KorzowskiDivision of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jon-Fredrik NielsenFunctional MRI Laboratory, Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Rolf F SchulteGE HealthCare, Munich, Germany.
Changhua MuDepartment of Radiology and Biomedical Imaging, University of California, California, USA.
Lucas CarvajalDepartment of Radiology and Biomedical Imaging, University of California, California, USA.
Duan XuDepartment of Radiology and Biomedical Imaging, University of California, California, USA.
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California, California, USA.ORCID 0000-0003-2760-4886
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California, California, USA.
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California, California, USA.
Zhen J WangDepartment of Radiology and Biomedical Imaging, University of California, California, USA.

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
A harmonized vendor-agnostic environment for multi-site functional MRI studiesU24NS120056 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jon-Fredrik Nielsen, Maxim Zaitsev · 2021 to 2026
$3.3M
Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor AggressivenessR01CA249909 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL, WANG, ZHEN JANE · 2021 to 2025
$3.2M
Imaging cerebral metabolic impairment in AD using Deuterium MRIR01AG080981 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy William Gordon, David M Wilson · 2023 to 2026
$2.7M
Hyperpolarized 13C MRI of Cardiac Metabolic Remodeling in Heart DiseaseR01HL171992 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Maria Roselle Abraham, Peder Eric Zufall Larson · 2024 to 2026
$2.4M
Translating Hyperpolarized 13C MRI as a Novel Tool to Predict Treatment Response in Pancreatic CancerR01CA280071 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy William Gordon, Zhen Jane Wang · 2024 to 2026
$2.0M
Upgrade of an Obsolete 3.35T DNP Polarizer to enable new HP C-13 Technology DevelopmentS10OD025077 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VIGNERON, DANIEL B · 2020 to 2020
$1.7M
Hyperpolarized 13C metabolic imaging in an endovascular swine model of ischemic strokeR21NS133531 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI JANOWSKI, MIROSLAW, MAYER, DIRK · 2023 to 2024
$425k
Deutschen Konsortium für Translationale KrebsforschungNCI NIH HHS R01 CA249909NCI NIH HHS R01 CA280071NHLBI NIH HHS R01 HL171992NIA NIH HHS R01 AG080981NIBIB NIH HHS P41 EB013598NIH HHS P41EB013598NIH HHS R01AG080981NIH HHS R01CA249099NIH HHS R01CA280071NIH HHS R21NS133531NIH HHS S10 OD025077NIH HHS S10OD025077NINDS NIH HHS R21 NS133531NINDS NIH HHS U24 NS120056UCSF Department of Radiology & Biomedical Imaging Seed Grant 24-01UCSF Department of Radiology & Biomedical Imaging Seed Grant 24-03
6 · The paper itself

Abstract

purposeCreate vendor-neutral modular sequences for X-nuclear acquisitions and build an X-nuclear-enabled Pulseq interpreter for GE (GE HealthCare, Waukesha, WI) scanners.

methodsWe designed a modular 2D gradient echo spiral sequence to support several sequence formats and a modular metabolite-specific 3D balanced steady-state free precession sequence for hyperpolarized (HP) carbon-13 (

resultsData from the

conclusionWe have designed a modular 2D gradient echo spiral sequence supporting several sequence formats and a modular metabolic-specific 3D balanced steady-state free precession sequence for

Indexed as

Image Processing, Computer-AssistedMagnetic Resonance ImagingAlgorithmsAnimalsBrainCarbon IsotopesHumansKidneyPhantoms, ImagingSoftwareCarbon Isotopesmulti‐vendor MRIopen sourcepulse sequence programmingvendor‐neutralX‐nuclear MRI

Identifiers

PMID40173321
PMCPMC12140903

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.