Evidence map›Paper›PMID 40173255›Full record

ArticleThe FEBS journal2025

First-in-class inhibitors of SbnA reduce siderophore production in Staphylococcus aureus.

Sarah Hijazi, Monica Cozzi, Somayeh Asgharpour, Omar De Bei, Serena Faggiano, Francesco Marchesani, Luca Ronda, Marialaura Marchetti, Eleonora Gianquinto, Mariacristina Failla and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Microbiology spectrum · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sarah HijaziDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Italy.ORCID https://orcid.org/0000-0002-0064-4610
Monica CozziDepartment of Medicine and Surgery, University of Parma, Italy.ORCID https://orcid.org/0000-0003-0794-5333
Somayeh AsgharpourDepartment of Drug Science and Technology, University of Turin, Italy.ORCID https://orcid.org/0000-0001-7999-4762
Omar De BeiDepartment of Medicine and Surgery, University of Parma, Italy.ORCID https://orcid.org/0000-0003-3916-8858
Serena FaggianoDepartment of Food and Drug, University of Parma, Italy.ORCID https://orcid.org/0000-0002-7447-9945
Francesco MarchesaniDepartment of Food and Drug, University of Parma, Italy.ORCID https://orcid.org/0000-0003-4384-9015
Luca RondaDepartment of Medicine and Surgery, University of Parma, Italy.ORCID https://orcid.org/0000-0002-5389-2669
Marialaura MarchettiDepartment of Medicine and Surgery, University of Parma, Italy.ORCID https://orcid.org/0000-0002-4615-6786
Eleonora GianquintoDepartment of Drug Science and Technology, University of Turin, Italy.ORCID https://orcid.org/0000-0003-0996-5936
Mariacristina FaillaDepartment of Drug Science and Technology, University of Turin, Italy.
Gauthier TrèvesDepartment of Drug Science and Technology, University of Turin, Italy.
Loretta LazzaratoDepartment of Drug Science and Technology, University of Turin, Italy.ORCID https://orcid.org/0000-0001-7100-8593
Francesca SpyrakisDepartment of Drug Science and Technology, University of Turin, Italy.
Barbara CampaniniDepartment of Food and Drug, University of Parma, Italy.ORCID https://orcid.org/0000-0003-0359-0627
Emanuela FrangipaniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Italy.ORCID https://orcid.org/0000-0001-5619-7912
Stefano BettatiDepartment of Medicine and Surgery, University of Parma, Italy.ORCID https://orcid.org/0000-0001-6787-0594

Funding

Ministero dell'Istruzione e del Merito 2020AE3LTA
6 · The paper itself

Abstract

Siderophore production, along with heme scavenging by hemophores, is one of the main mechanisms exploited by bacteria to achieve an adequate iron supply. Staphylococcus aureus produces two main siderophores, staphyloferrin A (SA) and staphyloferrin B (SB), with the latter produced only by the most invasive, coagulase-positive S. aureus strains. Along the seven steps of the SB biosynthetic pathway, N-(2-amino-2-carboxyethyl)-l-glutamate synthase (SbnA) catalyzes the crucial formation of the intermediate N-(2-amino-2-carboxyethyl)-l-glutamate from O-phospho-L-serine and glutamate. Our functional characterization of the enzyme highlighted that citrate inhibits SbnA with an inhibitory constant (K

Indexed as

Bacterial ProteinsEnzyme InhibitorsOrnithineSiderophoresStaphylococcus aureusCitratesIronBacterial ProteinsCitratesEnzyme InhibitorsIronOrnithineSiderophoresstaphyloferrin Astaphyloferrin Bantimicrobial resistanceiron metabolismSbnAsiderophoresStaphylococcus aureusstaphyloferrin B

Identifiers

PMID40173255
PMCPMC12414870

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.