Evidence map›Paper›PMID 40173228›Full record

ArticleScience advances2025

Contorted acene ribbons for stable and ultrasensitive neural probes.

Shayan Louie, Qifeng Jiang, Duncan J Wisniewski, Si Tong Bao, Honghu Zhang, Kaushik Chivukula, Qiyi Fang, Ashutosh Garudapalli, Scott R Docherty, Fay Ng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shayan LouieDepartment of Chemistry, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-8119-5679
Qifeng JiangDepartment of Chemistry, Columbia University, New York, NY 10027, USA.ORCID 0000-0002-5590-4889
Duncan J WisniewskiDepartment of Electrical Engineering, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-5405-1258
Si Tong BaoDepartment of Chemistry, Columbia University, New York, NY 10027, USA.
Honghu ZhangNational Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973, USA.ORCID 0000-0003-1784-7825
Kaushik ChivukulaDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-0440-9458
Qiyi FangDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-8435-636X
Ashutosh GarudapalliDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-2340-2083
Scott R DochertyDepartment of Chemistry, Columbia University, New York, NY 10027, USA.ORCID 0000-0002-8605-3669
Fay NgDepartment of Chemistry, Columbia University, New York, NY 10027, USA.
Michael SteigerwaldDepartment of Chemistry, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-6337-2707
Yu ZhongDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.
Dion KhodagholySamueli School of Engineering, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-0805-4612
Colin NuckollsDepartment of Chemistry, Columbia University, New York, NY 10027, USA.ORCID 0000-0002-0384-5493

Funding

Organic Closed-loop Electrochemical Array for Neurodevelopment (OCEAN)RF1NS128669 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KHODAGHOLY, DION · 2022 to 2022
$1.5M
NINDS NIH HHS RF1 NS128669
6 · The paper itself

Abstract

Organic materials that conduct both electrons and ions are integral to implantable bioelectronics because of their conformable nature. There is a dearth of these materials that are highly sensitive to cations, which are the majority ions on the surface of neurons. This manuscript offers a solution using an extended ribbon structure that is defect-free, providing high electronic mobility along its fused backbone, while the edge structure of these ribbons promotes high ionic conductivity. We incorporated these mixed ion/electron conductors into neural probes and implanted them in a rodent brain where they offer a suite of useful properties: high cation sensitivity, stability over several weeks after implantation, and biocompatibility. These materials represent an innovative class of implantable biosensors.

Indexed as

Biosensing TechniquesNeuronsAnimalsBiocompatible MaterialsBrainElectric ConductivityMiceRatsBiocompatible Materials

Identifiers

PMID40173228
PMCPMC11963965

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.