ArticleACS applied materials & interfaces2025
Hybrid Metasurface for On-Chip Enrichment and Quantification of Biological Samples.
Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Confined shear-induced structure discretization enables re-entrant super-repellent metals.Nature communications · 2026Article
- Defining Operational Limits of Low-Cost MSLA 3D Printing for Microfluidic Systems: Resin Performance, Cell Compatibility, and Fluid Dynamics.ACS omega · 2026Article
- Biomimetic 3D-PrintedACS applied materials & interfaces · 2026Article
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Authors and funding
8 authors.
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Abstract
This work reports a 3D-printed metasurface as a biosensing device that combines the functions of sample enrichment and quantification. The device consists of a nanoplasmonic sensing element surrounded by a biomimetic hydrophobic structure. The hydrophobic structure serves as a sample concentrator that can enrich analyte, which is subsequently quantified by the nanoplasmonic biosensor. Both the nanoscale biosensor and microscale hydrophobic sample concentrator were fabricated using two-photon polymerization lithography (TPL). The hydrophobic microstructure was inspired by natural patterns found on surfaces like lotus leaves, which are known for their water-repellent properties. The TPL-based 3D printing approach enables the integration of two functions into one chip with a high-resolution and simple fabrication process. The device was employed to detect swine influenza A virus within a droplet initially containing 20 μL of liquid. During testing, the droplet's volume decreased due to evaporation driven by plasmonic heating. As a result, the droplet's diameter can shrink from 3.4 mm to 0.1 mm in 15 min. The volume reduction corresponds to a virus concentration increase of over 4 × 10
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