ArticleCell reports2025
Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection.
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In one paragraph
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
–field-weighted citation impact
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Who cites it
13 citing papers in PubMed.
- Human Peripheral B Cell Subsets: Evolving notions about B cell biology and the broad relevance of B cells in disease.Immunological reviews · 2026Review
- Interferon-Mediated Regulation of Memory B Cell Identity and Function.Immunological reviews · 2026Review
- Germinal center-independent memory B cells provide rapid protection from lethal influenza challenges.bioRxiv : the preprint server for biology · 2026Article
- Identifying a Csmd3Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Atlas of human gut-associated lymphoid tissue reveals immunomodulatory interactions of B cells.Science immunology · 2026Article
- Dysregulation of anti-Ro60 B cell autoreactivity in systemic lupus erythematosus.bioRxiv : the preprint server for biology · 2026Article
- Germinal-centre and extrafollicular B cell pathways in systemic lupus erythematosus.Nature reviews. Rheumatology · 2026Review
- Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS-CoV-2 Vaccination.European journal of immunology · 2026Article
- Extrafollicular and other non-germinal center B cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis.Nature communications · 2026Article
- The pathogenic role of double-negative B cells in autoimmune diseases.Frontiers in immunology · 2026Review
- Towards antibody-based immunotherapy development for platinum-resistant high-grade serous ovarian cancer.Scientific reports · 2025Article
- Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors.
Cory A PeruginoRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Rheumatology Allergy and Immunology, Massachusetts General Hospital, Boston, MA 02114, USA.
Hang LiuRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Jared FeldmanRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Jess MarbourgAbbvie Cambridge Research Center, Cambridge, MA 02139, USA.
Thomas V GuyRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Anson HuiRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Nicole IngramRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Julian LiebaertRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Neha ChaudharyAbbvie Cambridge Research Center, Cambridge, MA 02139, USA.
Weiyang TaoAbbvie Cambridge Research Center, Cambridge, MA 02139, USA.
Catherine Jacob-DolanRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Monash University, Melbourne, VIC 3800, Australia.
Blake M HauserRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Zayd MianRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Anusha NathanRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Zezhou ZhaoRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Clarety KasekeRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Rhoda Tano-MenkaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Matthew A GetzRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Fernando SenjobeRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Cristhian BerriosDepartment of Pathology, Massachusetts Hospital, Boston, MA 02114, USA.
Onosereme OfomanDepartment of Pathology, Massachusetts Hospital, Boston, MA 02114, USA.
Zachary Manickas-HillRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Duane R WesemannDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Jacob E LemieuxInfectious Diseases Division, Massachusetts Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.
Marcia B GoldbergInfectious Diseases Division, Massachusetts Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Kerstin NündelUniversity of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Ann MoormannUniversity of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Ann Marshak-RothsteinUniversity of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Regina C LarocqueInfectious Diseases Division, Massachusetts Hospital, Boston, MA 02114, USA.
Edward T RyanInfectious Diseases Division, Massachusetts Hospital, Boston, MA 02114, USA.
John A IafrateMGH Cancer Center, Massachusetts Hospital, Boston, MA 02114, USA.
Daniel LingwoodRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Gaurav GaihaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Gastrointestinal Unit, Massachusetts Hospital, Boston, MA 02114, USA.
Richelle CharlesInfectious Diseases Division, Massachusetts Hospital, Boston, MA 02114, USA.
Alejandro B BalazsRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Aridaman PanditAbbvie Cambridge Research Center, Cambridge, MA 02139, USA.
Vivek NaranbhaiMGH Cancer Center, Massachusetts Hospital, Boston, MA 02114, USA; Monash University, Melbourne, VIC 3800, Australia; Center for the AIDS Programme of Research in South Africa, Durban 4001, South Africa.
Aaaron G SchmidtRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Shiv PillaiRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address: spillai@mgh.harvard.edu.
Funding
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MThe importance of the IgG4 glycome in IgG4-related disease(s)U19AI110495 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SHIV Subramaniam PILLAI · 2014 to 2026
$7.9MSARS-CoV-2 Variant TestingR01AI146785 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LINGWOOD, DANIEL · 2020 to 2024
$3.3MTriggering germline-encoded broadly neutralizing antibody responses against influenza virusR01AI153098 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BATISTA, FACUNDO DAMIAN, LINGWOOD, DANIEL · 2020 to 2023
$2.1MSystemic coordination of pro-inflammatory immune reactions through dendritic cell-restricted sIL6R biogenesisR01AI155447 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LINGWOOD, DANIEL · 2021 to 2025
$2.0MNCEZID CDC HHS U01 CK000490NCEZID CDC HHS U01 CK000633NIAID NIH HHS R01 AI146785NIAID NIH HHS R01 AI153098NIAID NIH HHS R01 AI155447NIAID NIH HHS U19 AI110495NIGMS NIH HHS T32 GM144273
Abstract
Memory lymphocytes are durable cells that persist in the absence of antigen, but few human B cell subsets have been characterized in terms of durability. The relative durability of eight non-overlapping human B cell sub-populations covering 100% of all human class-switched B cells was interrogated. Only two long-lived B cell populations persisted in the relative absence of antigen. In addition to canonical germinal center-derived switched-memory B cells with an IgD
Indexed as
B-LymphocytesB-Lymphocyte SubsetsImmunoglobulin Class SwitchingImmunologic MemoryMemory B CellsVaccinationGerminal CenterHumansImmunoglobulin DReceptors, CXCR5Tumor Necrosis Factor Receptor Superfamily, Member 7Immunoglobulin DReceptors, CXCR5Tumor Necrosis Factor Receptor Superfamily, Member 7clonal diversityCP: Immunologyextrafollicular memory B cellsgerminal center derived memory B cellshuman B cellshuman class-switched memory B cellshumoral immune durabilitylymphocyte durabilityTP63 in lymphocytes
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