Evidence map›Paper›PMID 40172968›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Structural basis for neutralizing antibody binding to pertussis toxin.

Jory A Goldsmith, Annalee W Nguyen, Rebecca E Wilen, Wassana Wijagkanalan, Jason S McLellan, Jennifer A Maynard

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jory A GoldsmithDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712.
Annalee W NguyenDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712.
Rebecca E WilenDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712.
Wassana WijagkanalanVaccine Discovery, BioNet-Asia Co. Ltd., Bangkok 10260, Thailand.
Jason S McLellanDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712.ORCID 0000-0003-3991-542X
Jennifer A MaynardDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712.ORCID 0000-0002-0363-8486

Funding

Protein-Glycan Interaction Resource at the National Center for Functional Glycomics (NCFG)R24GM137763 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RICHARD D CUMMINGS · 2020 to 2026
$5.8M
Structure, function and antigenicity of B. pertussis virulence factorsR01AI155453 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI MAYNARD, JENNIFER A, MCLELLAN, JASON SCOTT · 2021 to 2025
$2.8M
Cancer Prevention and Research Institute of Texas (CPRIT) RR160023HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI155453HHS | NIH | National Institute of General Medical Sciences (NIGMS) R24GM137763NIAID NIH HHS R01 AI155453NIGMS NIH HHS R24 GM137763Welch Foundation (The Welch Foundation) F-0003-19620604Welch Foundation (The Welch Foundation) F-1767
6 · The paper itself

Abstract

Pertussis toxin (PT) is a key protective antigen in vaccine- and natural immunity-mediated protection from

Indexed as

Antibodies, BacterialAntibodies, NeutralizingBordetella pertussisPertussis ToxinAnimalsBinding SitesCryoelectron MicroscopyEpitopesHumansModels, MolecularProtein BindingAntibodies, BacterialAntibodies, NeutralizingEpitopesPertussis Toxinantibodypertussistoxin

Identifiers

PMID40172968
PMCPMC12002313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.