Evidence map›Paper›PMID 40172960›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Allosterically switchable network orients

Lauren M Finn, Rebecca Cummer, Bastien Castagner, Bettina G Keller

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lauren M FinnDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin 14195, Germany.ORCID 0009-0009-0947-5217
Rebecca CummerDepartment of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3G 1Y6, Canada.ORCID 0009-0009-9336-0737
Bastien CastagnerDepartment of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3G 1Y6, Canada.ORCID 0000-0002-9207-1329
Bettina G KellerDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin 14195, Germany.ORCID 0000-0002-7051-0888

Funding

Canadian Insitutes of Health Research PJT-173262Deutsche Forschungsgemeinschaft (DFG) 434130070Natural Science and Engineering Research Council of Canada RGPIN-2020-04908
6 · The paper itself

Abstract

Allosteric proteins exhibit a functional response upon ligand binding far from the active site.

Indexed as

Bacterial ProteinsBacterial ToxinsClostridioides difficileAllosteric RegulationCatalytic DomainMolecular Dynamics SimulationPhytic AcidProtein BindingBacterial ProteinsBacterial ToxinsPhytic AcidallosteryClostridioides difficilefree energy surfacemolecular simulationsTcdB

Identifiers

PMID40172960
PMCPMC12002228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.