Evidence map›Paper›PMID 40172738›Full record

ArticleAnnals of biomedical engineering2025

A Regional Mapping of Articular Cartilage Integrity and Biphasic Properties in Healthy and Osteoarthritic Trapeziometacarpal Joints.

Lizzie Walker, Hui Li, Nathan Buchweitz, Daniel Gordon, Shangping Wang, Dane Daley, Hai Yao, Yongren Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lizzie WalkerDepartment of Bioengineering, Clemson University, Clemson, SC, USA.ORCID http://orcid.org/0009-0001-9980-6260
Hui LiDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Nathan BuchweitzDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Daniel GordonDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Shangping WangDepartment of Bioengineering, Clemson University, Clemson, SC, USA.ORCID http://orcid.org/0000-0003-0049-2212
Dane DaleyDepartment of Orthopaedics and Physical Medicine, Medical University of South Carolina, 68 President Street, BEB 203, Charleston, SC, 29425, USA.
Hai YaoDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Yongren WuDepartment of Bioengineering, Clemson University, Clemson, SC, USA. yongren@clemson.edu.ORCID http://orcid.org/0000-0002-5411-8528

Funding

Tissue Structural and Neural Remodeling in Human Sacroiliac JointP20GM121342 · NIGMS · CLEMSON UNIVERSITY · PI Peng Chen · 2018 to 2026
$24.7M
NIGMS NIH HHS P20 GM121342NIGMS NIH HHS P20GM121342
6 · The paper itself

Abstract

purposeTo identify the mechanical and morphological regional changes of articular cartilage on the first metacarpal and trapezium and their association with attenuation of the volar ligament complex (VLC) during trapeziometacarpal (TMC) osteoarthritis (OA) progression.

methodsTwenty-four fresh-frozen female cadaveric TMCs were separated into (1) younger healthy/early-stage osteoarthritic, (2) elder healthy/early-stage osteoarthritic, and (3) advanced-stage osteoarthritic groups based on age and Eaton-Littler grading. Metacarpal and trapezium surfaces were split into six regions. Microindentation testing was performed to characterize the biphasic properties of each region. Light imaging, scanning electron microscopy/energy dispersive spectroscopy, and magnetic resonance imaging were performed to assess cartilage integrity and identify wear patterns.

resultsThe volar ulnar region of the metacarpal, along with the volar central and volar ulnar regions of the trapezium, had a higher equilibrium modulus in the advanced-stage OA specimens. SEM/EDS revealed these regions to be fully eburnated in most cases. MRI revealed eburnation, as well as the degeneration and/or detachment of the beak ligament portion of the VLC. In the advanced-stage OA TMCs, an increased equilibrium modulus in the volar portion of the trapezium correlates to attenuated VLC stiffness from our previous study.

conclusionA regional pattern in articular cartilage degeneration, including changes in biphasic properties evidenced by an increased equilibrium modulus, during TMC OA progression is evident with the most significant changes occurring in the volar ulnar region of the metacarpal and volar central and volar ulnar regions of the trapezium. These changes in articular cartilage can be correlated to an attenuated VLC.

Indexed as

Carpometacarpal JointsCartilage, ArticularMetacarpal BonesOsteoarthritisTrapezium BoneAdultAgedAged, 80 and overFemaleHumansMiddle AgedAnterior oblique ligamentArticular cartilageBiphasic propertiesCarpometacarpal osteoarthritisTrapeziometacarpal osteoarthritisVolar ligament complex

Identifiers

PMID40172738
PMCPMC12075277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.