Evidence map›Paper›PMID 40172714›Full record

ArticleNeurosurgical review2025

Yellow enhance mode is useful for distinguishing tissues in endoscopic transnasal surgery: case series with preliminary results.

Hirotaka Hasegawa, Yuki Shinya, Motoyuki Umekawa, Satoshi Koizumi, Yoshiaki Goto, Satoshi Kiyofuji, Shunya Hanakita, Masahiro Shin, Masao Iwagami, Nobuhito Saito

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In one paragraph

Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hirotaka HasegawaDepartment of Neurosurgery, The University of Tokyo, Bunkyo, Tokyo, Japan. hirotaka.hasegawa@ymail.ne.jp.ORCID http://orcid.org/0000-0002-3585-2188
Yuki ShinyaDepartment of Neurosurgery, The University of Tokyo, Bunkyo, Tokyo, Japan.
Motoyuki UmekawaDepartment of Neurosurgery, The University of Tokyo, Bunkyo, Tokyo, Japan.
Satoshi KoizumiDepartment of Neurosurgery, The University of Tokyo, Bunkyo, Tokyo, Japan.
Yoshiaki GotoDepartment of Neurosurgery, Teikyo University, Itabashi, Tokyo, Japan.
Satoshi KiyofujiDepartment of Neurosurgery, The University of Tokyo, Bunkyo, Tokyo, Japan.
Shunya HanakitaDepartment of Neurosurgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Masahiro ShinDepartment of Neurosurgery, Teikyo University, Itabashi, Tokyo, Japan.
Masao IwagamiDepartment of Digital Health, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Nobuhito SaitoDepartment of Neurosurgery, The University of Tokyo, Bunkyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise tissue differentiation is vital in neurosurgery, especially during endoscopic endonasal surgery (ETS), where visual information is critical. The Yellow Enhance (YE) mode, a novel image-enhanced endoscopy technology, emphasizes yellow pigments to potentially improve tissue differentiation. This study retrospectively evaluated the efficacy of YE mode in five cases (two primary pituitary neuroendocrine tumors, one recurrent skull base-invasive pituitary neuroendocrine tumor, one pituitary apoplexy, and one recurrent craniopharyngioma) using the Olympus VISERA ELITE III endoscope. Eight experienced neurosurgeons reviewed surgical videos and provided 40 structured evaluations. Statistical analyses (Kruskal-Wallis and Mann-Whitney U tests) compared scores among cases. Gross or near-total resection was achieved in all cases without neurological complications. YE mode improved differentiation between normal pituitary tissue and tumors in 80% of cases, but was less effective in cases like pituitary apoplexy with degenerative changes. Across 40 evaluations, 68% rated YE mode as "useful" or "somewhat useful," while 20% noted limited utility in complex cases, such as recurrent craniopharyngiomas. YE mode shows promise in enhancing visual differentiation during ETS, particularly for normal pituitary tissue, but its utility depends on tissue characteristics. Larger prospective studies are needed to validate these findings and explore broader applications in neurosurgery.

Indexed as

CraniopharyngiomaNeuroendocrine TumorsNeuroendoscopyNeurosurgical ProceduresPituitary NeoplasmsAgedFemaleHumansMaleMiddle AgedPituitary GlandRetrospective StudiesEndoscopic transnasal surgeryImage-enhanced endoscopyNeuroendoscopePituitary neoplasm

Identifiers

PMID40172714
PMCPMC11965165

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.