Evidence map›Paper›PMID 40172692›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Vancomycin-based tracers guiding in situ visualization of bacteria on osteosynthesis devices and surgical debridement.

Gerbren B Spoelstra, Philip H Elsinga, Jan Maarten van Dijl, Johannes H van Snick, Ben L Feringa, Andor W J M Glaudemans, Bas Keizers, Schelto Kruijff, Wiktor Szymanski, Marleen van Oosten and 1 more

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The dual role of the microbiome in chronic wound management.Cell communication and signaling : CCS · 2026
    Review
  3. A scoping review on potential of novel developments in fever of unknown origin and inflammation of unknown origin: long-axial-field-of-view positron emission tomography/computed tomography and novel radiotracers.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gerbren B SpoelstraDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands.ORCID 0000-0002-7063-2834
Philip H ElsingaDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands.ORCID 0000-0002-3365-4305
Jan Maarten van DijlDepartment of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands.ORCID 0000-0002-5688-8438
Johannes H van SnickDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands.ORCID 0009-0008-0417-1823
Ben L FeringaStratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, Groningen, 9747 AG, The Netherlands.ORCID 0000-0003-0588-8435
Andor W J M GlaudemansDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands.ORCID 0000-0001-8081-0641
Bas KeizersDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands.ORCID 0000-0003-3798-7702
Schelto KruijffDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands.ORCID 0000-0002-5151-7320
Wiktor SzymanskiDepartment of Radiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands.ORCID 0000-0002-9754-9248
Marleen van OostenDepartment of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands.ORCID 0000-0002-7061-6324
Frank F A IJpmaDepartment of Trauma Surgery, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands. f.f.a.ijpma@umcg.nl.ORCID 0000-0002-9420-2732

Funding

Stichting voor de Technische Wetenschappen 16895
6 · The paper itself

Abstract

purposeBacterial infections associated with musculoskeletal injuries are challenging to detect and distinguish from sterile inflammation. Here we present the combined first-time application of a bacteria-targeted positron emission tomography (PET) tracer and a near-infrared fluorescent tracer to detect infected osteosynthesis implants and guide surgical treatment.

methodsTo this end, osteosynthesis plates covered with bacterial biofilm and pre-incubated with [

resultsPre-debridement, PET imaging showed a significant 2.2-fold higher tracer uptake on biofilm-covered plates compared to plates without biofilm (p < 0.001). Post-debridement, the PET signal was marginal, demonstrating effective biofilm removal. Fluorescence-guided surgery enabled real-time visualization and removal of bacterial biofilms.

conclusionCombined preoperative PET and intraoperative fluorescence imaging with vancomycin-based tracers allows noninvasive detection and real-time infection management, as demonstrated by these preliminary findings.

Indexed as

DebridementVancomycinBiofilmsHumansMalePositron Emission Tomography Computed TomographyRadioactive TracersRadioactive TracersVancomycinBacterial biofilmBacterial imaging agentsDebridementFluorescence guided surgeryFracture-related infectionsHuman post-mortemNear infrared fluorescencePositron emission tomographyVancomycin

Identifiers

PMID40172692
PMCPMC12316776

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.