Evidence map›Paper›PMID 40172688›Full record

ReviewEuropean archives of psychiatry and clinical neuroscience2026

Disorganisation and depression: a re-examination of how we think and speak when depressed.

Lena Palaniyappan, Yingqi Laetitia Wang, Fiona Meister

Abstract readReview
PubMed Publisher
In one paragraph

Review in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Increasing participation of people with thought disorder in clinical research.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Review
  4. Review
  5. Linking spontaneous speech, cognition, and psychopathology across affective and psychotic disorders: A network approach.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lena PalaniyappanDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Quebec, Canada. lena.palaniyappan@mcgill.ca.ORCID http://orcid.org/0000-0003-1640-7182
Yingqi Laetitia WangRobarts Research Institute & Lawson Health Research Institute, London, ON, Canada.
Fiona MeisterDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Quebec, Canada.

Funding

Fonds de Recherche du Québec - Santé PIQ-J/338282Institute of Neurosciences, Mental Health and Addiction PJT195903Strategy for Patient-Oriented Research PJK192157
6 · The paper itself

Abstract

Disorganised thinking in severe mental illness seriously cripples social functions. Historically, the study of disorganisation has primarily concentrated on schizophrenia, utilizing tools designed to assess formal thought disorder (FTD). This review examines the characteristics, prevalence, and possible neural correlates of FTD within the framework of depressive disorders. Our focus is on disturbances in thought, language, and communication associated with depression, alongside the relevant subjective experiences. We also discuss the challenges and opportunities in using FTD as a predictor of future illness trajectory and advocate for using the broader construct of depressive disorganisation. We review the disruption of brain networks associated with FTD, such as the salience, language, and default mode networks, within the context of depression. In conclusion, we advocate for increased focus on personal narratives, computational psychopathology, and a broader emphasis on thought dynamics to enhance the identification of disorganisation in depression. Renewed emphasis on this neglected area of psychopathology could provide insights on improving employment and social functioning for individuals affected by mood disorders.

Indexed as

Depressive DisorderNerve NetThinkingHumansAcousticsBipolar disorderLanguageMoodPsychosisSemantics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.