Evidence map›Paper›PMID 40172680›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Physical activity and risk of cancer mortality in patients with and without cancer: is there a dose-response relationship?

Xiaosheng Dong, Meng Ding, Nuo Yi, Xiao Hou, Chengchao Zhou, Xiangren Yi

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Xiaosheng DongDepartment of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Meng DingCollege of Physical Education, Shandong Normal University, Jinan, China.
Nuo YiCHRISTUS HEALTH, Canton, TX, USA.
Xiao HouSchool of Sport Sciences, Beijing Sport University, Beijing, China.
Chengchao ZhouDepartment of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China. zhouchengchao@sdu.edu.cn.
Xiangren YiDepartment of Sport and Health, School of Physical Education, Shandong University, Jinan, China. xrenyi@sdu.edu.com.

Funding

China Postdoctoral Science Foundation 2023M742059Natural Science Foundation of Shandong Province ZR2024QG047Postdoctoral Innovation Project of Shandong Province SDCX-RS-202400011
6 · The paper itself

Abstract

backgroundThe purpose of this study was to examine a dose-response association between aerobic physical activity (APA) and muscle-strengthening exercise (MSE) and their combinations with cancer mortality.

methodsThe final 575,439 participants involved in this study were derived from 1997 to 2018 longitudinal follow-up data collected in the National Health Interview Survey (NHIS). The APA and MSE were requested via self-reported questionnaires. These records are linked to the National Death Index and classified as cancer deaths based on the International Classification of Diseases (ICD-10). Statistical analysis was performed by Wilcoxon rank-sum test, chi-square test, and the Cox proportional hazards models.

resultsAfter adjusting for all covariates, the results demonstrated that the cancer mortality risk for cancer survivors decreased by 23.2%, 35.8%, 42.5%, and 46.7% for those engaging in 0-7.4 MET hours/week, 7.5-14.9 MET hours/week, 15-29.9 MET hours/week, and 30 + MET hours/week, respectively. For non-cancer patients, the cancer mortality risk decreased by 6.9%, 11.9%, 15.1%, and 16.7%. Furthermore, the results showed that the cancer mortality risk for cancer survivors decreased by 34.9%, 30.2%, 32.3%, and 10% for those engaging in 2-3 times/week, 4-5 times/week, 6-7 times/week, and 8 + times/week. For non-cancer patients, the cancer mortality risk decreased by 17.4%, 23.7%, 9.5%, and 10.6%. Among non-cancer patients with insufficient MSE, there was no significant negative correlation between APA and cancer mortality.

conclusionThe optimal dose response in reducing the risk of cancer mortality may occur at higher levels of APA with MSE 4-5 times/week and 2-3 times/week for primary and secondary prevention. In addition, primary prevention derives a greater advantage from MSE, and a protocol of APA should be emphasized in secondary prevention.

Indexed as

Cancer SurvivorsExerciseNeoplasmsAdultAgedFemaleHealth SurveysHumansLongitudinal StudiesMaleMiddle AgedResistance TrainingRisk FactorsCancer mortalityDose–responsePhysical activity

Identifiers

PMID40172680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.