Trial reportIndian pediatrics2025
Intramuscular Versus Oral Ondansetron for Management of Children with Acute Dehydrating Diarrhea and Vomiting: A Randomized Controlled Trial.
Trial report in Indian pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare efficacy and safety of intramuscular (IM) ondansetron with oral ondansetron for improving utilization of Oral Rehydration Therapy (ORT) by controlling vomiting in children with acute diarrhea and some dehydration.
methodsWe enrolled children aged 3 months to 12 years presenting with acute diarrhea (duration < 14 days) with some dehydration, and at least two episodes of vomiting within last 6 h in an open-label randomized controlled trial. Participants were randomized to receive single dose (0.2 mg/kg) of IM or oral ondansetron before starting ORT. Primary outcome was failure of ORT (persistence of some dehydration after 4 h of ORT or need for intravenous fluids). Secondary outcomes included need for unscheduled intravenous fluids, amount of Oral Rehydration Salt Solution (ORS) ingested after 4 h, frequency of vomiting episodes, adverse effects, and caregiver satisfaction.
resultsWe randomized 60 children (31 IM, 29 oral); 58 (29 per group) were followed-up for all outcomes. There were no significant differences between IM and oral routes in terms of ORT failure (31% vs. 24.1%; RR (95% CI) 1.3 (0.5, 3.0), P = 0.557), need for IV fluids during ORT (24.1% vs. 20.7%; P = 0.753), mean (SD) ORS ingested (mL) in 4 h [616.2 (429.7) vs. 645.5 (403.5); P = 0.79], mean (SD) frequency of vomiting [1.4 (2.0) vs. 2.3 (2.4); P = 0.107] or caregiver satisfaction. No adverse events attributable to the intervention were observed.
conclusionIntramuscular ondansetron may not offer any advantage over oral use in management of children with acute diarrhea with vomiting and some dehydration.
trial registrationClinical Trials Registry-India (CTRI/2020/01/023082) available at ctri.nic.in.
Indexed as
Identifiers
40172592What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.