ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025
Cross-sectional Associations of Neighborhood Social and Environmental Contextual Factors with Telomere Length in Male and Female Health Professionals.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTelomere length attrition has been proposed as a mediator through which the adverse neighborhood social and environmental context affects cancer risk through stress-related pathways, but associations have been inconsistent. We examined associations between neighborhood social and environmental factors in a population with extensive capture of behavioral factors and comorbidities.
methodsData were pooled from nested case-control studies using blood samples collected in two large prospective US-based cohorts of male (n = 3,065) and female (n = 9,993) health professionals. Relative leukocyte telomere length was assayed using qPCR and geospatial measures of socioeconomic status, air pollution, green space, and temperature were linked to participants' address at blood draw.
resultsAfter adjusting for sociodemographic and lifestyle covariates, no statistically significant associations of relative leukocyte telomere length with any of the address-level neighborhood socioeconomic or environmental factors were observed.
conclusionsIn this large nation-wide cross-sectional study of male and female health professionals in the United States, neighborhood social and environmental contextual factors were not associated with telomere length. IMPACT: Further cross-sectional studies of associations between neighborhood social and environmental factors and telomere length are unlikely to improve understanding of this potential mediating mechanism. Studies with repeated measures may be required.
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