Evidence map›Paper›PMID 40172563›Full record

ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2025

Sensitivity analysis for exploring the variability and parameter landscape in virtual patient cohorts of multi-vessel coronary artery disease.

Pjotr Hilhorst, Bregje van de Wouw, Karol Zajac, Marcel van 't Veer, Pim Tonino, Frans van de Vosse, Wouter Huberts

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. A Comparison of Coupling Strategies for 1D-3D Simulations of Coronary Hemodynamics.International journal for numerical methods in biomedical engineering · 2025
    Article
  3. Article
  4. Preface to the theme issue 'Uncertainty quantification for healthcare and biological systems (Part 2)'.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pjotr HilhorstDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Noord-Brabant, The Netherlands.ORCID 0000-0003-1764-1536
Bregje van de WouwDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Noord-Brabant, The Netherlands.
Karol ZajacSano Centre for Computational Medicine, Extreme-Scale Data and Computing Team, Kraków, Poland.ORCID 0000-0003-1393-8236
Marcel van 't VeerDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Noord-Brabant, The Netherlands.
Pim ToninoDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Noord-Brabant, The Netherlands.
Frans van de VosseDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Noord-Brabant, The Netherlands.ORCID 0000-0002-4084-2064
Wouter HubertsDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Noord-Brabant, The Netherlands.

Funding

European Union's Horizon 2020 research and innovation programme under grant agreement SanoH2020 In Silico World: Lowering barriers to ubiquitous adoption of In Silico Trials
6 · The paper itself

Abstract

Virtual patient cohorts (VPC) are crucial in

Indexed as

Coronary Artery DiseaseModels, CardiovascularCohort StudiesComputer SimulationHumanscorrelated sensitivity analysisfractional flow reserveone-dimensional pulse wave propagation modelreduced-order modellingvirtual cohort generatorsvirtual patient cohorts

Identifiers

PMID40172563
PMCPMC11966647

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.