Evidence map›Paper›PMID 40172491›Full record

ArticleInfection and immunity2025

Sejeong Lee, Antzela Tsavou, Robert Zarnowski, Rita Pforte, Stefanie Allert, Thomas Krüger, Olaf Kniemeyer, Axel A Brakhage, Tam T T Bui, David R Andes and 3 more

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. International journal of molecular sciences · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sejeong LeeCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.ORCID 0000-0001-8617-3436
Antzela TsavouCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.
Robert ZarnowskiDepartment of Medicine, Infectious Disease Division, School of Medicine & Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-6343-1500
Rita PforteDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll Institute, Jena, Thuringia, Germany.
Stefanie AllertDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll Institute, Jena, Thuringia, Germany.
Thomas KrügerDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll-Institute, Jena, Thuringia, Germany.ORCID 0000-0001-8984-3853
Olaf KniemeyerDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll-Institute, Jena, Thuringia, Germany.
Axel A BrakhageDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll-Institute, Jena, Thuringia, Germany.ORCID 0000-0002-8814-4193
Tam T T BuiCentre for Biomolecular Spectroscopy and Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom.
David R AndesDepartment of Medicine, Infectious Disease Division, School of Medicine & Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-7927-9950
Jonathan P RichardsonCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.ORCID 0000-0001-9638-2725
Bernhard HubeDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knöll Institute, Jena, Thuringia, Germany.ORCID 0000-0002-6028-0425
Julian R NaglikCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.ORCID 0000-0002-8072-7917

Funding

Vesicle-mediated drug resistance of Candida albicans biofilmR01AI073289 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ANDES, DAVID R, MITCHELL, AARON P · 2008 to 2025
$7.9M
Host and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6M
IL-17 Receptor Signaling in the Oral MucosaR01DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2012 to 2016
$2.1M
Deutsche Forschungsgemeinschaft (DFG) 210879364 project C1 C2 and Z2Deutsche Forschungsgemeinschaft (DFG) project Hu 528/20-1Deutsche Forschungsgemeinschaft (DFG) project number 390713860HHS | National Institutes of Health (NIH) DE022550HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) NIH-NIAID R01AI073289NIAID NIH HHS R01 AI073289NIDCR NIH HHS R01 DE022550NIDCR NIH HHS R37 DE022550the Leibniz Association Campus InfectoOptics SAS-2015-HKI-LWCWellcome TrustWellcome Trust (WT) 214229_Z_18_Z
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are heterogeneous particles encapsulated with a phospholipid bilayer membrane. EVs have evolved diverse biological functions, serving mainly as prominent mediators and regulators of cell-cell communication. This study investigated whether candidalysin, a key virulence factor in

Indexed as

BiofilmsCandida albicansCell MembraneEpithelial CellsExtracellular VesiclesFungal ProteinsCytokinesHost-Pathogen InteractionsHumansCytokinesECE1 protein, Candida albicansFungal ProteinsCandida albicanscandidalysincell membranesextracellular vesiclesfungal infectionhost-pathogen interactionshost responsemembrane transport

Identifiers

PMID40172491
PMCPMC12070735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.