ArticleMovement disorders clinical practice2025
Does Midbrain Atrophy Distinguish Progressive Supranuclear Palsy from Frontotemporal Dementia?
Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Cognitive impairment on the Alzheimer's Disease Centers' Uniform Data Set Version 3 Neuropsychological Test Battery in a Peruvian population with progressive supranuclear palsy.Arquivos de neuro-psiquiatria · 2026Article
- Midsagittal Midbrain Area and Midbrain-to-Pons-Ratio Cannot Distinguish Overlap Syndromes Between Amyotrophic Lateral Sclerosis and Progressive Supranuclear Palsy.Clinical neuroradiology · 2026Article
- Brain atrophy and cholinergic denervation in progressive supranuclear palsy: an MRI and [Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe diagnostic value of midbrain atrophy for distinguishing behavioral variant frontotemporal dementia (bvFTD) from progressive supranuclear palsy (PSP) is unclear.
objectiveTo investigate whether measures of midbrain atrophy differentiate PSP from bvFTD.
methodsWe included four groups: healthy controls (n = 19), PSP-Richardson syndrome (n = 20), bvFTD (n = 19) and Parkinson's disease (PD; n = 12). The following quantitative and qualitative measures were calculated: Hummingbird sign rating scale [HBS-RS], global midbrain atrophy [GMA], midbrain area, midbrain/pons ratio, the Magnetic Resonance Parkinsonism Index (MRPI), the MRPI 2.0 and brainstem volume.
resultsCompared to controls, PSP and bvFTD had lower values of midbrain area, HBS-RS and GMA, and higher MRPI and MRPI 2.0. HBS-RS, GMA, midbrain/pons ratio, midbrain area, MRPI, MRPI 2.0 and brainstem volume distinguished PSP from bvFTD with 73%, 67%, 75%, 83%, 71%, 69% and 82% accuracies, respectively.
conclusionsBoth quantitative and qualitative measures of midbrain atrophy provided modest accuracy in distinguishing PSP from bvFTD.
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Registered trials
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