Evidence map›Paper›PMID 40172223›Full record

ArticlemBio2025

Forward genetic screen in zebrafish identifies new fungal regulators that limit host-protective

Bailey A Blair, Emma Bragdon, Gursimran Dhillon, Nnamdi Baker, Lena Stasiak, Mya Muthig, Pedro Miramon, Michael C Lorenz, Robert T Wheeler

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. mBio · 2026
    Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Bailey A BlairDepartment of Molecular & Biomedical Sciences, University of Maine, Orono, Maine, USA.
Emma BragdonDepartment of Molecular & Biomedical Sciences, University of Maine, Orono, Maine, USA.
Gursimran DhillonDepartment of Molecular & Biomedical Sciences, University of Maine, Orono, Maine, USA.
Nnamdi BakerDepartment of Molecular & Biomedical Sciences, University of Maine, Orono, Maine, USA.
Lena StasiakDepartment of Molecular & Biomedical Sciences, University of Maine, Orono, Maine, USA.
Mya MuthigDepartment of Molecular & Biomedical Sciences, University of Maine, Orono, Maine, USA.
Pedro MiramonDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0002-6867-7697
Michael C LorenzDepartment of Microbiology and Molecular Genetics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0002-7881-8027
Robert T WheelerDepartment of Molecular & Biomedical Sciences, University of Maine, Orono, Maine, USA.ORCID 0000-0003-3223-7021

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Characterization of novel virulence factors in CandidaR01AI143304 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LORENZ, MICHAEL C · 2019 to 2024
$2.6M
Genetic determinants of bacterial-drug synergy against CandidaR15AI169393 · NIAID · UNIVERSITY OF MAINE ORONO · PI WHEELER, ROBERT T. · 2023 to 2023
$435k
Burroughs Wellcome Fund PATHNational Institute of Allergy and Infectious Diseases 1R15AI169393National Institute of Allergy and Infectious Diseases R01AI143304NIAID NIH HHS R01 AI143304NIAID NIH HHS R15 AI169393NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20GM103423
6 · The paper itself

Abstract

IMPORTANCE:

Indexed as

Candida albicansCandidiasisHost-Pathogen InteractionsImmunity, InnateZebrafishAnimalsDisease Models, AnimalFungal ProteinsGenetic TestingImmune EvasionMutationPhagocytesPhagocytosisVirulenceVirulence FactorsFungal ProteinsVirulence FactorsCandidaimmune evasioninnate immunitymacrophagesneutrophilsphagocytosisvirulence determinantszebrafish

Identifiers

PMID40172223
PMCPMC12077120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.