Evidence map›Paper›PMID 40172222›Full record

ArticlemSphere2025

Metabolic adaptability and nutrient scavenging in

Patrick A Rimple, Einar B Olafsson, Benedikt M Markus, Fengrong Wang, Leonardo Augusto, Sebastian Lourido, Vern B Carruthers

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. bioRxiv : the preprint server for biology · 2026
    Article
  2. A pooled image-based CRISPR screen identifies EAF1 as abioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Dense granule proteins: key mediators ofFrontiers in medicine · 2026
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Patrick A RimpleDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0009-0000-6834-8343
Einar B OlafssonDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Benedikt M MarkusWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.ORCID 0000-0002-6823-9072
Fengrong WangDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Leonardo AugustoDepartment of Pathology and Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0003-0430-8216
Sebastian LouridoWhitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.ORCID 0000-0002-5237-1095
Vern B CarruthersDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-6859-8895

Funding

Translational Imaging and Behavioral Assessment (TIBA) CoreP20GM130447 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Anna Dunaevsky · 2020 to 2026
$20.7M
Parasite autophagy as a key survival mechanism for the AIDS-associated pathogen Toxoplasma gondiiR01AI120607 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 2016 to 2025
$4.0M
Control of parasite invasion by a microneme protein complex conserved in ApicomplexansR01AI144369 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2020 to 2024
$2.4M
Defining a novel protein network for Toxoplasma repurposing of host ESCRT machineryR21AI180278 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 2024 to 2025
$422k
Boehringer Ingelheim FondsNational Institute of Allergy and Infectious Diseases R01AI120607National Institute of Allergy and Infectious Diseases R01AI144369NIAID NIH HHS R01 AI120607NIAID NIH HHS R01 AI144369NIAID NIH HHS R21 AI180278NIGMS NIH HHS P20 GM130447NIGMS NIH HHS P20GM130447
6 · The paper itself

Abstract

The obligate intracellular parasite IMPORTANCE:

Indexed as

NutrientsToxoplasmaCRISPR-Cas SystemsEndocytosisMutationProtozoan ProteinsVacuolesNutrientsProtozoan Proteinsamino acidsCRISPRmetabolismToxoplasma gondii

Identifiers

PMID40172222
PMCPMC12039266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.