ArticleMicrobiology spectrum2025
Epitope mapping targeting the K205R protein of African swine fever virus using nanobody as a novel tool.
Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Nanobodies in animal infectious disease control: diagnosis and therapy.Frontiers in cellular and infection microbiology · 2025Review
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Authors and funding
11 authors.
Funding
Abstract
African swine fever (ASF) is a highly infectious and lethal swine disease, leading to enormous losses in the pig industry. K205R, a non-structural protein of ASF virus (ASFV), is abundantly expressed at the early stages of viral infection and induces a strong immune response. In our previous study, five strains of K205R-specific nanobodies (Nbs) were screened through phage display technology, among which Nb1, Nb14, Nb35, and Nb82 exhibited good affinity. In the present study, the above four Nbs were successfully expressed in HEK293T cells and exhibited strong reactivity. Four Nbs recognized linear B-cell epitopes of K205R in both prokaryotic and eukaryotic expression systems. Besides, four Nbs specifically reacted with the K205R protein of ASFV-infected cells. Two epitopes
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Registered trials
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