Evidence map›Paper›PMID 40172212›Full record

ArticlemBio2025

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in

Mayara S Bertolini, Sabrina E Cline, Miguel A Chiurillo, Brian S Mantilla, Aharon Eidex, Logan P Crowe, Danye Qiu, Henning J Jessen, Adolfo Saiardi, Roberto Docampo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mayara S BertoliniDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Sabrina E ClineDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Miguel A ChiurilloDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Brian S MantillaDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Aharon EidexDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Logan P CroweDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Danye QiuInstitute of Organic Chemistry & CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Baden-Württemberg, Germany.
Henning J JessenInstitute of Organic Chemistry & CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Baden-Württemberg, Germany.
Adolfo SaiardiMedical Research Council Laboratory for Cell Biology, University College London, London, England, United Kingdom.
Roberto DocampoDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID 0000-0003-4229-8784

Funding

Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
Georgia Veterinary Scholars Summer Research ProgramT35OD010433 · OD · UNIVERSITY OF GEORGIA · PI SUSAN SANCHEZ · 2012 to 2026
$846k
Polyphosphate and cardiac fibrosis by Trypanosoma cruziR21AI173402 · NIAID · UNIVERSITY OF GEORGIA · PI DOCAMPO, ROBERTO · 2023 to 2024
$415k
American Heart Association 24POST1196440Deutsche Forschungsgemeinschaft 390939984Medical Research Council MR/T028904/1National Institute of Allergy and Infectious Diseases AI173402NIAID NIH HHS R21 AI173402NIAID NIH HHS T32 AI060546NIH HHS T32AI060546NIH HHS T35 OD010433NIH HHS T35OD010433Volkswagen Foundation 98604
6 · The paper itself

Abstract

Inositol phosphates are involved in a myriad of biological roles and activities such as Ca IMPORTANCE: Millions of people are infected with

Indexed as

Carbohydrate MetabolismInositol PhosphatesSphingolipidsTrypanosoma cruziType C PhospholipasesSaccharomyces cerevisiaeInositol PhosphatesSphingolipidsType C Phospholipasesinositol phosphoceramideinositol pyrophosphatesphospholipase CsphingolipidsTrypanosoma cruzi

Identifiers

PMID40172212
PMCPMC12077091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.