Evidence map›Paper›PMID 40172147›Full record

ArticleClinical and experimental dental research2025

Comparative Study of the Expressions of Nuclear (∆EX3) and Cytoplasmic (2B) Survivins in Oral Squamous Cell Carcinoma and Oral Lichen Planus Using Real-Time PCR.

Maryam Amirchaghmaghi, Atessa Pakfetrat, Nooshin Mohtasham, Farnaz Mohajertehran, Mohammad Taghi Shakeri, Elahe Vazavandi

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Maryam AmirchaghmaghiOral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-6504-2725
Atessa PakfetratOral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0003-0480-6442
Nooshin MohtashamOral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-1262-4668
Farnaz MohajertehranDental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0001-6266-4281
Mohammad Taghi ShakeriSocial Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-8287-9594
Elahe VazavandiDepartment of Oral and Maxillofacial Medicine, School of Dentistry, Kerman university of Medical Science, Kerman, Iran.ORCID 0000-0001-7143-2394

Funding

The study was supported by the Mashhad University of Medical Sciences (992125).
6 · The paper itself

Abstract

objectiveSurvivin is used to determine the prognosis and clinical features of premalignant and malignant lesions. The aim of this study was to determine the correlation between the expression of survivin isoforms and clinical outcomes in oral lichen planus and oral squamous cell carcinoma. MATERIALS AND

methodsThis cross-sectional study examined 119 cases, including oral squamous cell carcinoma (SCC), oral lichen planus (OLP), and healthy margins of lesions. For all lesions, survivin expression was assessed quantitatively and qualitatively using real-time polymerase chain reaction. The data were analyzed using SPSS 20.

resultsThe expression of survivin-∆EX3 and survivin-2B were quantitatively and qualitatively higher in SCC and OLP cases than in healthy mucosa (p < 0.05). The mean expression of survivin-∆EX3 in erosive OLP (4.95 ± 4.41) was higher than that in nonerosive OLP (2.13 ± 3.32, p < 0.05). Moreover, the mean expression of both genes was significantly higher in different grades of SCC compared to healthy mucosa (p < 0.05). There was also a significant correlation between gene expressions (p < 0.001).

conclusionThe increased expression of survivin-∆EX3 and survivin-2B in OSCC correlates with tumor progression and advanced clinical stages, suggesting a potential prognostic role.

Indexed as

Carcinoma, Squamous CellInhibitor of Apoptosis ProteinsLichen Planus, OralMouth NeoplasmsSurvivinAdultAgedBiomarkers, TumorCell NucleusCross-Sectional StudiesCytoplasmFemaleHumansMaleMiddle AgedReal-Time Polymerase Chain ReactionBiomarkers, TumorBIRC5 protein, humanInhibitor of Apoptosis ProteinsSurvivingene expressionneoplasmoral lichen planussquamous cell carcinomasurvivin

Identifiers

PMID40172147
PMCPMC11963071

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