Evidence map›Paper›PMID 40172095›Full record

SynthesisJournal of medical virology2025

The Burden of HPV Infections and HPV-Related Diseases Among People With HIV: A Systematic Literature Review.

Bekana K Tadese, Xuedan You, Tidiane Ndao, Joseph E Tota, Ya-Ting Chen, Alisa Chowdhary, Jia Pan, Ana C Costa, Nelly Mugo

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bekana K TadeseMerck & Co., Inc., Rahway, New Jersey, USA.ORCID 0000-0001-5173-5427
Xuedan YouMerck & Co., Inc., Rahway, New Jersey, USA.
Tidiane NdaoMerck & Co., Inc., Rahway, New Jersey, USA.
Joseph E TotaMerck & Co., Inc., Rahway, New Jersey, USA.
Ya-Ting ChenMerck & Co., Inc., Rahway, New Jersey, USA.
Alisa ChowdharyAdelphi Values PROVE™, Adelphi Mill, Bollington, UK.
Jia PanAdelphi Values PROVE™, Adelphi Mill, Bollington, UK.
Ana C CostaAdelphi Values PROVE™, Adelphi Mill, Bollington, UK.
Nelly MugoKenya Medical Research Institute, Nairobi City, Kenya.

Funding

This study was funded by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co. Inc. Rahway, NJ, USA.
6 · The paper itself

Abstract

Human papillomavirus (HPV) is associated with a significant global burden of precancerous lesions and cancer. People with HIV (PWH) are at higher risk of HPV infection and HPV-related diseases. This systematic review was conducted to synthesize data on the burden of HPV infection and HPV-related diseases among PWH. Studies published between January 2018-June 2023 were sourced from databases and conferences. Included were 221 publications containing epidemiological data on HPV infections and the clinical burden of HPV-related diseases among PWH. The burden varied by geographical region, age, sex, and sexual orientation. Compared to people without HIV (PWoH), PWH had higher prevalence and incidence of HPV infection and HPV-related diseases. Among PWH, the prevalence of anal HPV infection ranged between 44% and 83%; men had a higher prevalence and incidence of anogenital warts than women. The incidence of anal HPV infection was over two-fold greater among transgender women with HIV and men who have sex with men with HIV than among their respective counterparts without HIV. Incident HPV-related anal cancer was up to two-fold higher among PWH than PWoH, and incident cervical cancer was up to six times higher among women with HIV than those without. The most prevalent high-risk (hr) HPV genotypes with HPV-related disease were vaccine genotype HPV16/18/52/58. HPV35 was one of the most prevalent genotypes with anal or cervical HPV infection among PWH of African descent. PWH also have a higher burden of concurrent HPV infections and HPV-related diseases. This study calls for strengthening appropriate HPV vaccine delivery and increasing vaccine uptake among this high-risk group, potentially by integrating HPV vaccination with routine HIV care.

Indexed as

HIV InfectionsPapillomavirus InfectionsAnus NeoplasmsCost of IllnessFemaleHumansIncidenceMalePapillomaviridaePrevalenceRisk FactorsUterine Cervical Neoplasmscervical cancerHIVHPVHPV‐related cancerhuman papillomavirusPWH

Identifiers

PMID40172095
PMCPMC11963496

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.