Evidence map›Paper›PMID 40172079›Full record

ArticleThe Journal of physiology2025

Activation of TRPA1 and TRPM3 triggers Ca

Yaroslav E Andrianov, Alex L Keyes, Charles A Warwick, Miriam C McDonough, Leonid P Shutov, Kavita S Solanki, Jon M Resch, Alexander G Bassuk, Nana Voitenko, Pavel Belan and 1 more

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The therapeutic pipeline in migraine: What does the future hold?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yaroslav E AndrianovDepartment of Neuroscience & Pharmacology and The Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0001-6954-0767
Alex L KeyesDepartment of Neuroscience & Pharmacology and The Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-0414-5608
Charles A WarwickDepartment of Neurobiology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6244-9821
Miriam C McDonoughDepartment of Neuroscience & Pharmacology and The Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-0481-324X
Leonid P ShutovDepartment of Neuroscience & Pharmacology and The Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0003-0102-965X
Kavita S SolankiDepartment of Neuroscience & Pharmacology and The Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0009-0004-7760-3245
Jon M ReschDepartment of Neuroscience & Pharmacology and The Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-5409-7771
Alexander G BassukDepartments of Pediatrics and Neurology, The Iowa Neuroscience Institute and the Hawkeye Intellectual and Developmental Disabilities Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-4067-2157
Nana VoitenkoDepartment of Biomedicine and Neuroscience, Kyiv Academic University, Kyiv, Ukraine.ORCID 0000-0002-2450-3134
Pavel BelanDepartment of Biomedicine and Neuroscience, Kyiv Academic University, Kyiv, Ukraine.ORCID 0000-0001-5429-3716
Yuriy M UsachevDepartment of Neuroscience & Pharmacology and The Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA.ORCID 0000-0002-6948-4627

Funding

Diabetes Research Training Program Diversity SupplementT32DK112751 · NIDDK · UNIVERSITY OF IOWA · PI Andrew W Norris · 2017 to 2026
$4.8M
Interdisciplinary Training Program in Pain ResearchT32NS045549 · NINDS · UNIVERSITY OF IOWA · PI KATHLEEN A SLUKA, Yuriy M Usachev · 2004 to 2026
$3.7M
The Role of the Complement System in Spinal Mechanisms of Chronic PainR01NS113189 · NINDS · UNIVERSITY OF IOWA · PI USACHEV, YURIY M · 2019 to 2023
$2.2M
The mitochondrial Ca2+ uniporter in the regulation of neural activity and susceptibility to seizuresR01NS125884 · NINDS · UNIVERSITY OF IOWA · PI Yuriy M Usachev · 2022 to 2026
$2.2M
Novel Circuits and Mechanisms of Descending Pain ModulationR01NS127428 · NINDS · UNIVERSITY OF IOWA · PI ALEXANDER G BASSUK, Yuriy M Usachev · 2023 to 2026
$2.1M
NIDDK NIH HHS T32 DK112751NINDS NIH HHS R01 NS113189NINDS NIH HHS R01 NS125884NINDS NIH HHS R01 NS127428NINDS NIH HHS T32 NS045549
6 · The paper itself

Abstract

Transient receptor potential ankyrin 1 (TRPA1) and melastatin 3 (TRPM3) are transduction channels of sensory neurons that play major roles in peripheral mechanisms of somatosensation, including thermosensation, chemosensation and nociception. Recent studies suggest that both channels also contribute to central mechanisms of pain processing at the spinal cord level. TRPA1 and TRPM3 are highly permeable for Ca

Indexed as

Calcium SignalingPosterior Horn CellsSensory Receptor CellsSpinal Cord Dorsal HornTRPA1 Cation ChannelTRPM Cation ChannelsAnimalsCalciumMaleMiceMice, Inbred C57BLCalciumTRPA1 Cation ChannelTrpa1 protein, mouseTRPM3 protein, mouseTRPM Cation ChannelsCa2+ imagingdorsal hornsensory synapsespinal cordTRPA1TRPM3TRPV1

Identifiers

PMID40172079
PMCPMC12559988

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.