ArticleBiology open2025
trithorax is an essential regulator of cardiac Hox gene expression and anterior-posterior patterning of the Drosophila embryonic heart tube.
Article in Biology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- In Vivo Models of Cardiovascular Disease:Biomedicines · 2025Review
- Article
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7 authors.
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Abstract
The precise regulation of transcription required for embryonic development is partially controlled by the actions of the Trithorax group (TrxG) and Polycomb group (PcG) proteins. The genes trithorax (trx), trithorax-related (trr), and SET domain containing 1 (Set1) encode COMPASS-like histone methyltransferases, a subgroup of TrxG proteins that impart H3K4 methylation modifications onto chromatin in order to activate and maintain transcription. In this study, we identify the role of these genes in the development of the embryonic heart of the fruit fly Drosophila melanogaster. trx, trr, and Set1 independently ensure proper cardiac cell divisions. Additionally, trx regulation of collinear Hox expression is necessary for the anterior-posterior cardiac patterning of the linear heart tube. trx inactivation in Drosophila results in a remarkable homeotic transformation of the posterior heart-proper segment into an aorta-like fate due to the loss of posterior abdominal A expression. Furthermore, cardiac expression of Antennapedia, Ultrabithorax, and Abdominal B is also deregulated in trx mutants. Together, these data suggest that the COMPASS-like histone methyltransferases are essential developmental regulators of cardiogenesis, being necessary for both cardiac cell divisions and heart patterning.
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