Evidence map›Paper›PMID 40171991›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

C1q

Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang and 2 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. C1qAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yunzhi LiuClinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.ORCID https://orcid.org/0000-0001-6140-3522
Cuicui HuangClinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Min LuoClinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Wenfu LuDepartment of Surgery, Division of Otolaryngology, Head and Neck Surgery, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Baifeng ZhangClinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Lu BaiClinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Shuyue ZhengClinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Yanan TanClinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Shanshan LiClinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Huali WangClinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Lanqi GongClinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.
Xinyuan GuanClinical Oncology Center, Shenzhen Key Laboratory for cancer metastasis and personalized therapy, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China.ORCID https://orcid.org/0000-0002-4485-6017

Funding

Collaborative Research Funds C7026-18GFCollaborative Research Funds C7065-18GFGuangdong Basic and Applied Basic Research Foundation 2023A1515111086Hong Kong Research Grant Council 17143716National Nature Science Foundation of China 82072738National Nature Science Foundation of China 82103643Shenzhen Medical Research Fund A2303055Shenzhen Science and Technology Program JCYJ20220818103012025Shenzhen Science and Technology Program JCYJ20220818103014030Shenzhen Science and Technology Program KQTD20180411185028798Shenzhen Science and Technology Program RCBS20200714114959020Shenzhen Science and Technology Program RCBS20231211090737068Shenzhen Science and Technology Program ZDSYS20210623091811035Theme-based Research Scheme T12-703/23-NTheme-based Research Scheme T12-704/16-R
6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is one of the common head and neck cancers in Southern China and Southeast Asia. Although current studies have adequately characterized the tumor microenvironment (TME) of NPC, little attention has been paid to how cell-cell interactions within the TME promote tumorigenesis. In this study, it is found that C1q

Indexed as

CarcinogenesisComplement C1qDNA MethylationMacrophagesNasopharyngeal CarcinomaNasopharyngeal NeoplasmsReceptors, G-Protein-CoupledAnimalsCell CommunicationCell Line, TumorFemaleHumansMaleMicePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktADGRG1 protein, humanComplement C1qPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptors, G-Protein-CoupledC1qDNA hypermethylationnasopharyngeal carcinomaPI3K/AKT signalingtumor‐associated macrophage

Identifiers

PMID40171991
PMCPMC12244503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.