Evidence map›Paper›PMID 40171974›Full record

ArticleThe Prostate2025

Effect of Dendritic Cells Injection After Radical Prostatectomy on Prostate Cancer in Mice.

Xiaoli Zhang, Weicong Sang, Xiaoping Hong, Haihong Qu, Jindong Tong, Qingtong Yi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Prostate, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoli ZhangDepartment of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, China.
Weicong SangShanghai Jiao Tong University Medical College, Shanghai, China.
Xiaoping HongDepartment of Nursing, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, China.
Haihong QuDepartment of Nursing, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, China.
Jindong TongDepartment of Vascular Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, China.
Qingtong YiDepartment of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, China.ORCID 0000-0001-7167-3024

Funding

This study was supported by Science and Technology Development Fund of Shanghai Pudong New Area (Grant No. PKJ2019-Y29), Outstanding Leaders Training Program of Pudong Health Committee of Shanghai (Grant No. PWRl2023-04), Talents Training Program of Shanghai Pudong Hospital (Grant No. LJ202203), Key Medical Discipline of Pudong Hospital of Fudan University (Grant No. Zdxk2020-04), the Multidisciplinary Team for Urinary Incontinence and Pelvic Floor Diseases of Shanghai Pudong Hospital (Grant No. MDT2021-06), Major Weak Discipline Construction Project of Pudong Health and Family Planning Commission of Shanghai (Grant No. PWZbr2022-20), the Project of Key Medical Specialty and Treatment Center of Pudong Hospital of Fudan University(Grant No. Zdzk2020-01 to RZ), Talents Training Program of Shanghai Pudong Hospital(Grant No. LJ202203 to RZ), Outstanding Leaders Training Program of Pudong Health Committee of Shanghai (Grant No. PWRl2023-04 to RZ) and Medical Key Subspecialty Department of Shanghai Pudong Health System (Grant No. PWZy2020-13).
6 · The paper itself

Abstract

backgroundTo explore the therapeutic and preventive effect of dendritic cells injection combined with radical prostatectomy on prostate cancer in mice.

methodsWe extracted antigens from mouse prostate cancer cells RM-1 and cocultured them with dendritic cells to induce maturation. We constructed in situ carcinoma and subcutaneous tumor models of the mouse prostate. The efficacy of dendritic cell injection combined with radical prostatectomy was evaluated in the carcinoma in situ model, and the ability of dendritic cells to prevent prostate cancer was evaluated in the subcutaneous tumor model. Means of assessment included ultrasonography, flow cytometry analysis, and Elisa.

resultsDendritic cell injection combined with radical prostatectomy effectively inhibited the growth of prostate carcinoma in situ in mice, as well as the growth of subcutaneous tumors of prostate cancer in mice. After dendritic cell injection, the levels of CD4 + T cells and Treg cells in the spleens of mice were significantly increased, and the levels of IL-2 and TNF-γ in the peripheral serum were significantly increased.

conclusionsInjection of mature dendritic cells induced by mouse prostate cancer cell RM-1 antigen can inhibit the growth of prostate cancer. Radical prostatectomy combined with dendritic cell injection might be a potential treatment strategy for prostate cancer.

Indexed as

Dendritic CellsProstatectomyProstatic NeoplasmsAnimalsCell Line, TumorMaleMiceMice, Inbred C57BLcell therapydendritic cellsprostate cancerradical prostatectomytumor immunology

Identifiers

PMID40171974
PMCPMC12068033

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.