ReviewCurrent opinion in HIV and AIDS2025
Immune signatures and biomarkers of viral control in early-treated children with HIV: insights informing intervention.
Review in Current opinion in HIV and AIDS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Stepping stones to cure in children with HIV.Current opinion in HIV and AIDS · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purpose of reviewThis review concentrates on the immune signatures in infants with perinatally acquired HIV (PAH) and in later life to assess their utility in predicting the likelihood of HIV remission following discontinuation of antiretroviral therapy. RECENT
findingsDistinct immune signatures are identifiable in early treated infants with PAH in whom reservoirs are markedly restricted, with high CD4 + /CD8 + ratios, decreased immune activation and exhaustion, and a rapid transition of CD8 + T cells from naïve to a terminally differentiated state. The natural killer (NK) cell compartments manifest downregulated inhibitory markers and exhibit cytokine producing NK phenotypes. Immune signatures observed in adolescent/adult cohorts with PAH, and associated with reduced or absent replication competent HIV reservoir included HIV-specific T cell proliferative responses and NK cells expressing the activation markers NKG2D and NKp46. SUMMARY: Immune signatures of functional T cell and NK cell compartments are identifiable in early treated infants and adolescents with PAH, and are associated with limited replication competent reservoirs. Such findings are also observed in post treatment controllers and could be predictors of ART-free remission.
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Registered trials
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