Evidence map›Paper›PMID 40171799›Full record

Trial reportJournal of the American Geriatrics Society2025

Home-Based Rehabilitation After Transcatheter Aortic Valve Replacement (REHAB-TAVR): A Pilot Randomized Controlled Trial.

Sandra M Shi, Faith-Anne Rapley, Heather Margulis, Roger J Laham, Kimberly Guibone, Edward Percy, Tsuyoshi Kaneko, Kuan-Yuan Wang, Dae Hyun Kim

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02805309 (Home-Based Exercise Program For Recovery After Transcatheter Aortic Valve Replacement), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02805309 nacompletednot on this map

Home-Based Exercise Program For Recovery After Transcatheter Aortic Valve Replacement: A Pilot Study

TypeinterventionalSponsorBrigham and Women's HospitalRan2017 to 2020Enrolled64ConditionsAortic Valve StenosisArmsExercise, Cognitive behavioral interventions, Attention control education program
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sandra M ShiFrailty Research Center, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.ORCID 0000-0001-6801-5602
Faith-Anne RapleyClinical Research Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Heather MargulisRehabilitation Services, Hebrew SeniorLife, Boston, Massachusetts, USA.
Roger J LahamHarvard Medical School, Boston, Massachusetts, USA.
Kimberly GuiboneDivision of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Edward PercyDivision of Cardiac Surgery, Department of Surgery, University of British Columbia, Vancouver, Canada.
Tsuyoshi KanekoDepartment of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Kuan-Yuan WangFrailty Research Center, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.ORCID 0000-0002-5004-2159
Dae Hyun KimFrailty Research Center, Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.ORCID 0000-0001-7290-6838

Funding

TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Thomas Glenn Travison · 2008 to 2026
$23.9M
Core B - Pilot StudiesP30AG048785 · NIA · BRANDEIS UNIVERSITY · PI LACHMAN, MARGIE E · 2014 to 2023
$4.5M
Mid-Career Mentoring Award For Patient-Oriented Research in Frailty and Health OutcomesK24AG073527 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI Dae Hyun Kim · 2022 to 2026
$862k
Boston Claude D. Pepper Older Americans Independence Center Pilot, NIA P30AG031679Boston Roybal Center Pilot, NIA P30AG048785NIA NIH HHS K24 AG073527NIA NIH HHS K24AG073527NIA NIH HHS P30 AG031679NIA NIH HHS P30 AG048785
6 · The paper itself

Abstract

backgroundThe benefit of early cardiac rehabilitation after transcatheter aortic valve replacement (TAVR) is not well established. This pilot study evaluated the feasibility and short-term effects of a home-based exercise program, with or without cognitive-behavioral intervention (CBI).

methodsWe randomized 51 patients (mean age, 83.9 years; 19 women) to a home-based exercise program with CBI (Group A; n = 18) or without CBI (Group B; n = 15), or telephone-based education control (Group C; n = 18). The exercise program focusing on balance, flexibility, strength, and endurance began within 7 days post-discharge and was delivered once weekly by a physical therapist for 8 weeks. CBI included discussions on exercise benefits and barriers, goal setting, detailed exercise planning, and a weekly cash adherence incentive. The primary outcome was a disability score (range: 0-22; higher scores indicate greater disability) at 8 weeks. Secondary outcomes included the Short Physical Performance Battery (SPPB) (range: 0-12; higher scores indicate better function), self-efficacy, and outcome expectation scores. Feasibility outcomes included adherence and drop-out rates.

resultsFifteen participants (83.3%) in Group A, 10 (58.8%) in Group B, and 10 (52.6%) in Group C completed ≥ 5 of the eight assigned weekly sessions (p = 0.196). Two participants in each group were lost to follow-up. At 8 weeks, the home-based exercise groups (Group A and B combined) demonstrated lower disability scores (mean [SE]: 2.6 [0.3] vs. 4.5 [0.5]; p = 0.042) and higher SPPB scores (9.5 [0.6] vs. 6.5 [0.8]; p = 0.003) compared with the education group (Group C). Group A had lower disability scores than Group B (2.1 [0.4] vs. 3.4 [0.5]; p = 0.047), with no differences in self-efficacy and outcome expectation scores.

conclusionsAn early, home-based, multi-domain exercise program appears feasible and may prevent disability and improve physical function in older adults after TAVR. Adding CBI, including a modest cash incentive, showed trends toward improved adherence and reduced disability.

trial registrationNCT02805309.

Indexed as

Aortic Valve StenosisCardiac RehabilitationCognitive Behavioral TherapyExercise TherapyHome Care ServicesTranscatheter Aortic Valve ReplacementAgedAged, 80 and overFeasibility StudiesFemaleHumansMalePilot ProjectsTreatment Outcomerandomized controlled trialrehabilitationtranscatheter aortic valve replacement

Identifiers

PMID40171799
PMCPMC12213202

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.