Evidence map›Paper›PMID 40171666›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Preeclamptic Placental CD19+ B Cells Are Causal to Hypertension During Pregnancy.

Owen Thomas Herrock, Nathan Campbell, Evangeline Deer, Lorena M Amaral, Darby Whitney, Rachael Morris, Kedra Wallace, Ty Warren Turner, E Hawthorne Cleveland, Sheila Belk and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Immune Cells in Preeclampsia.International journal of molecular sciences · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Owen Thomas HerrockDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.
Nathan CampbellDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.ORCID 0000-0003-0518-4219
Evangeline DeerDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.ORCID 0000-0001-8004-5978
Lorena M AmaralDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.
Darby WhitneyDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.
Rachael MorrisDepartment of Obstetrics and Gynecology (R.M., B.L.), University of Mississippi Medical Center, Jackson.
Kedra WallaceDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.ORCID 0000-0003-4511-0046
Ty Warren TurnerDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.ORCID 0000-0001-9660-4447
E Hawthorne ClevelandDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.
Sheila BelkDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.
George W BoozDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.ORCID 0000-0003-1478-9615
Denise C CorneliusDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.ORCID 0000-0002-6730-6499
Babbette LaMarcaDepartment of Pharmacology and Toxicology (O.T.H., N.C., E.D., L.M.A., D.W., K.W., T.W.T., E.H.C., S.B., G.W.B., D.C.C., B.L.), University of Mississippi Medical Center, Jackson.ORCID 0000-0002-3340-6088

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI MASON, SARAH · 2016 to 2025
$38.2M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Ashley C. Johnson, Babbette LaMarca · 2017 to 2026
$26.4M
Resource Support Core (RSC)U54HL170290 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jan Michael Williams · 2025 to 2026
$4.4M
The Kidney, Hypertension, Pregnancy and InflammationR01HD067541 · NICHD · UNIVERSITY OF MISSISSIPPI MED CTR · PI LAMARCA, BABBETTE · 2011 to 2020
$3.1M
Hypertension, Inflammation, and Vascular FunctionR01HL151407 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2020 to 2024
$1.9M
Sex differences in hypertension, cognitive function and renal hemodynamics; a role for B cells and autoantibodiesR01HL170622 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Babbette LaMarca · 2024 to 2026
$1.5M
The Role of AT1-AA in Causing Adult Hypertension in Offspring Born with FGRF31HD110230 · NICHD · UNIVERSITY OF MISSISSIPPI MED CTR · PI CAMPBELL, NATHAN E. · 2022 to 2023
$48k
NHLBI NIH HHS R01 HL151407NHLBI NIH HHS R01 HL170622NHLBI NIH HHS U54 HL170290NICHD NIH HHS F31 HD110230NICHD NIH HHS R01 HD067541NIGMS NIH HHS P20 GM121334NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

backgroundPatients with preeclampsia exhibit hypertension and chronic inflammation characterized by CD (cluster determinant) 4+T cells, B cells secreting AT1-AA (agonistic autoantibody against the angiotensin II type 1 receptor), inflammatory cytokines, and complement activation. Importantly, a history of COVID-19 during pregnancy is associated with an increased incidence of a preeclampsia-like phenotype and is partly mediated by CD4+T cells. We recently showed pregnant patients with a history of COVID-19 with or without preeclampsia produce AT1-AA, indicating the importance of B lymphocytes in the progression of preeclampsia and possibly of COVID-19. Therefore, we hypothesize that B cells from patients with preeclampsia with or without COVID-19 history induce the preeclampsia phenotype through AT1-AA.

methodsPlacental B cells were isolated from normal pregnant, patients with preeclampsia, normotensive COVID-19 history, or preeclampsia COVID-19 history at delivery. Then, 3×10

resultsPreeclampsia B-cell recipients had significantly increased mean arterial pressure, AT1-AA, inflammatory cytokines, and complement activation compared with normal pregnant B-cell recipients. Recipients of B cells with COVID-19 history had markers of inflammation and hypertension but not to the level of significance as recipients of preeclampsia B cells. Inhibition of AT1-AA attenuated the hypertension that occurred in response to preeclampsia or preeclampsia B cells with COVID-19 history.

conclusionsThis study demonstrates the important role of B cells in contributing to hypertension and chronic inflammation during preeclampsia with or without COVID-19 history through secretion of AT1-AA.

Indexed as

Antigens, CD19B-LymphocytesCOVID-19HypertensionPlacentaPre-EclampsiaAdultAnimalsDisease Models, AnimalFemaleHumansPregnancyRatsReceptor, Angiotensin, Type 1SARS-CoV-2Antigens, CD19Receptor, Angiotensin, Type 1angiotensin IIhypertensioninflammationpre-eclampsiapregnancy

Identifiers

PMID40171666
PMCPMC12003061

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.