Evidence map›Paper›PMID 40171538›Full record

ArticleFrontiers in cardiovascular medicine2025

Association of myocardial and liver T2* iron measurements with systolic and diastolic function by CMR feature tracking strain analysis.

Hugo G Quezada-Pinedo, Benedikt Bernhard, Jan C Zurkirchen, Anselm W Stark, Noushin Sadat Ahanchi, Catherine Gebhard, Daniel Ott, Alan A Peters, Hendrik von Tengg-Kobligk, Jonathan Schütze and 5 more

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Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hugo G Quezada-PinedoDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, United States.
Benedikt BernhardDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Jan C ZurkirchenDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Anselm W StarkDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Noushin Sadat AhanchiInstitute of Social and Preventive Medicine (ISPM), Graduate School of Health Sciences, University of Bern, Bern, Switzerland.
Catherine GebhardDepartment of Population Health Sciences, Duke University School of Medicine, Durham, NC, United States.
Daniel OttDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Alan A PetersDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Hendrik von Tengg-KobligkDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Jonathan SchützeDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Adam BakulaDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Andreas WahlDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Kim N Cajachagua-TorresDepartment of Pediatrics, New York University Grossman of Medicine, New York University, New York, NY, United States.
Taulant MukaEpistudia, Bern, Switzerland.
Christoph GräniDepartment of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Objectives: Myocardial and liver iron overload can be assessed through T2* in magnetic resonance imaging (MRI). It is unclear, how T2* measurements are associated with systolic and diastolic left ventricular function assessed by novel feature tracking (FT) strain. Methods: Consecutive patients with suspected iron overload undergoing MRI T2* were retrospectively included. T2* was studied continuously and in categories: normal myocardial iron status (T2* ≥ 20 ms), myocardial iron overload (T2* < 20 ms), normal liver iron status (T2* ≥ 15.4 ms) and liver iron overload (T2* < 15.4 ms). Multivariable regression models were used to assess associations between T2* and FT strain. Results: Among 172 participants, longitudinal e/a ratio [-0.17 (-0.27, -0.08), Conclusion: Liver and a combination of myocardial and liver iron overload were associated with increased early diastolic filling and increased e/a ratio respectively, which may serve as markers of diastolic dysfunction. Impaired diastolic function, even in the absence of myocardial iron overload was associated with liver iron metabolism and may indicate early cardiac involvement, while left ventricular systolic function is still preserved.

Indexed as

diastolic functionfeature trackingiron overloadretrospective studiesstrainT2*

Identifiers

PMID40171538
PMCPMC11958997

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