Evidence map›Paper›PMID 40171497›Full record

ArticleEC psychology and psychiatry2024

Methylome-wide association studies of psychiatric disorders.

Qiao Mao, Zhixiong Luo, Xiaoping Wang, Kesheng Wang, Zhiren Wang, Yong Zhang, Xingguang Luo

Abstract read
PubMed Full text at PMC
In one paragraph

Article in EC psychology and psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiao MaoDepartment of Psychosomatic Medicine, People's Hospital of Deyang City, Deyang, Sichuan 618000, China.
Zhixiong LuoCollege of Integrative Medicine, Fujian University of Traditional Medicine, Fuzhou 350122, China.
Xiaoping WangDepartment of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Kesheng WangDepartment of Family and Community Health, School of Nursing, Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA.
Zhiren WangBeijing Huilongguan Hospital, Peking University Huilongguan Clinical School of Medicine, Beijing 100096, China.
Yong ZhangInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin 300222, China.
Xingguang LuoDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.

Funding

Post-GWAS transcriptome-wide LncRNA expression profiling in alcohol dependenceR21AA023237 · NIAAA · YALE UNIVERSITY · PI LUO, XINGGUANG · 2015 to 2016
$344k
NIAAA NIH HHS R21 AA023237
6 · The paper itself

Abstract

Neuroepigenetics underscores the significance of the methylome in both normal and pathological brain function, influencing neurobiological processes and psychiatric well-being. This study systematically examines methylome-wide association studies (MWAS) across various psychiatric disorders that utilize array-based and sequencing approaches on blood or brain tissue samples. The findings provide valuable insights into the early stages of neuropathogenesis in psychiatric disorders, revealing altered epigenetic mechanisms. The methylome emerges as a pivotal factor in the development and treatment of psychiatric conditions, potentially offering avenues for identifying therapeutic targets and informing treatment strategies.

Indexed as

CpG islandMethylome-wide association studymicroarrayPsychiatric disordersSequencing

Identifiers

PMID40171497
PMCPMC11960846

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.