Evidence map›Paper›PMID 40171345›Full record

ArticleCureus2025

Unilateral Papulopustular Dermatosis: Demodex Mites Bridging Rosacea and Demodicosis.

Jesús Iván Martínez-Ortega, Tiffany Karoly Medina Angulo, Jacqueline E Mut Quej

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jesús Iván Martínez-OrtegaDermatology, Dermatology Institute of Jalisco, Zapopan, MEX.
Tiffany Karoly Medina AnguloGeneral Practice, Autonomous University of Campeche, Campeche, MEX.
Jacqueline E Mut QuejInternal Medicine, Regional General Hospital No. 12 Lic. Benito Juárez, Yucatán, MEX.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Papulopustular rosacea (PPR) is a common inflammatory dermatosis often associated with Demodex mite proliferation, though its pathogenesis remains incompletely understood. While bilateral presentations predominate, unilateral cases are rare and may offer unique insights into disease mechanisms. We report a case of a 68-year-old female with a chronic erythematous and scaly rash confined to the right malar region. Standardized skin surface biopsy revealed a high Demodex density (>5 mites/cm²), confirming demodicosis. Treatment with topical ivermectin cream resulted in significant improvement within four weeks. This case underscores the importance of considering demodicosis in the differential diagnosis of atypical facial dermatoses and revisits the classification, pathogenesis, diagnostic algorithm, and treatment strategies for inflammatory facial conditions. The findings support the inclusion of Demodex proliferation in disease frameworks and its potential impact on tailored therapeutic approaches.

Indexed as

atypical facial dermatosesdemodex folliculorumdemodex-related skin conditionsdemodicosispapulopustular demodicosispapulopustular rosaceaskin immunologytopical ivermectinunilateral facial dermatosisunilateral rosacea

Identifiers

PMID40171345
PMCPMC11959103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.