Risk of Depression and Anxiety in Those Who Gave Birth to Children Who Developed Invasive

Background: Mental disorders such as depression and anxiety are common for women of reproductive age and impact pregnancy and parenting. Invasive Materials and Methods: Using Danish healthcare registries from 1997 to 2018, we obtained data on iGBS-affected children and their birthing parents. A comparison cohort was randomly sampled (1:50) through risk-set sampling, and matched on persons' age, year of child´s birth, and parity. The risk of using antidepressant medicines and depression or anxiety diagnosis was analyzed with cumulative incidence function and in Cox proportional hazards regression models. Results: During the study period, we identified 1,552 women with iGBS-affected child and 76,879 matched comparators. During a median follow-up of 9∙9 years, the cumulative incidence of antidepressants use among birthing parents with iGBS-affected children was 31% (95% confidence interval, CI: 28-34%), as compared with 29% (95% CI: 28-30%) among members of the comparison cohort (hazard ratio 1∙12 [95% CI: 1∙01-1∙25]). A 16% increase in the rate of diagnosed depression or anxiety was observed in the overall follow-up period. Conclusion: Our findings provide evidence of a slightly increased risk of antidepressant use and diagnosed depression or anxiety in parents who gave birth to children with a history of iGBS compared to a matched cohort of birthing parents whose infants did not develop iGBS. Our findings highlight the importance of addressing the mental health needs of birthing parents affected by their children' iGBS.